10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation.

Abstract

Rikkunshito (RKT), a Japanese traditional medicine, has been shown to stimulate food intake in rats with cisplatin-induced anorexia; however, the underlying mechanisms remain unknown. In this study, we investigated whether RKT is involved in the degradation of peripheral ghrelin. RKT inhibited decreases in plasma ghrelin level and enhanced acyl- to desacyl-ghrelin (A/D) ratio in cisplatin-treated rats. Several components of RKT demonstrated inhibitory activity against ghrelin deacylating enzymes. In addition, 10-gingerol, a component of RKT, inhibited exogenous ghrelin deacylation. Therefore, RKT may enhance plasma acyl-ghrelin level, at least in part, by inhibiting the circulating ghrelin degrading enzyme.

• Authors: Chiharu Sadakane, Shuichi Muto, Koji Nakagawa, Shunsuke Ohnishi, Yayoi Saegusa, Miwa Nahata, Tomohisa Hattori, Masahiro Asaka, Hiroshi Takeda
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 412 Issue 3 Pg. 506-11 (Sep 02 2011) ISSN: 1090-2104 [Electronic] United States
• PMID: 21846463 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Catechols
• Drugs, Chinese Herbal
• Fatty Alcohols
• Ghrelin
• liu-jun-zi-tang
• gingerol
• Carboxylesterase
• Cisplatin

Topics

• Acylation
• Animals
• Anorexia (chemically induced, drug therapy)
• Carboxylesterase (antagonists & inhibitors)
• Catechols (therapeutic use)
• Cisplatin (pharmacology)
• Drugs, Chinese Herbal (therapeutic use)
• Fatty Alcohols (therapeutic use)
• Ghrelin (blood, metabolism, pharmacology)
• Male
• Rats
• Rats, Sprague-Dawley