Abstract | OBJECTIVE: Our objective was to assess the short-term effect of an estrogen cream on symptoms associated with provoked vestibulodynia. METHODS: We undertook a double-blind randomized trial in women who had experienced dyspareunia satisfying the Friedrichcriteria for at least three months. We compared the daily application of 3 g of vaginal cream containing 1.875 g of conjugated estrogens for six weeks ( estrogen group) with the application of a comparable cream without estrogens (placebo group). The main outcome was modification of dyspareunia,determined by a visual analogue scale of pain from the pretreatment period to the post-treatment period. Secondary outcomes were colposcopic evaluation of the vulva and pain reported during the swab test. RESULTS: Of 69 women randomized, 61 participated for the full duration of the trial. Dyspareunia was significantly lessened in both groups ( estrogen group: 7.4 ± 1.9 pre-treatment vs. 4.8 ± 3.0 post-treatment, P < 0. 01; placebo group:7.1 ± 1.9 vs. 4.9 ± 2. 7, P < 0.01), but the difference observed in terms of decrease between the two groups was not found to be significant (P = 0.5). Alternatively, the group treated with estrogen cream showed (1) a more substantial decrease of the pain reported at the orifices of the Bartholin’s glands when palpated with a swab (P < 0.01), and (2) a decrease of the inflammation observed at the orifices of the Bartholin’s glands orifices and the posterior fourchette (P < 0.01). CONCLUSION:
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Authors | Sylvie Bazin, Jessica Lefebvre, Michel Fortier, Jacques Brisson, François Brouillette, Emmanuel Bujold, Céline Bouchard |
Journal | Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
(J Obstet Gynaecol Can)
Vol. 33
Issue 8
Pg. 838-843
(Aug 2011)
ISSN: 1701-2163 [Print] Netherlands |
Vernacular Title | [Évaluation d'une crème œstrogénique vaginale dans le traitement de la vestibulodynie provoquée : essai randomisé à double insu]. |
PMID | 21846439
(Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Estrogens, Conjugated (USP)
- Vaginal Creams, Foams, and Jellies
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Topics |
- Adult
- Double-Blind Method
- Dyspareunia
(drug therapy, physiopathology)
- Estrogens, Conjugated (USP)
(administration & dosage)
- Female
- Humans
- Pain Measurement
- Treatment Outcome
- Vaginal Creams, Foams, and Jellies
(administration & dosage)
- Young Adult
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