Abstract | BACKGROUND/OBJECTIVE: An inflammation of the cutis and subcutis of the external auditory canal is a primary symptom in cases of acute otitis externa. It is usually treated locally, since this type of therapy ensures a high concentration of the drug and interacts at the site of inflammation with no systemic effects. This systematic review compares the efficacy of treatment using a ciprofloxacin 0.2% solution with other therapeutic options. METHODS: After compiling a catalog of search terms, medical databases were searched systematically for randomized, controlled studies. This search initially yielded a total of 38 studies which were then evaluated by three independent reviewers. The number of studies was subsequently reduced to 14: six studies using a ciprofloxacin 0.2% solution, and eight studies using both 0.2% and 0.3% solutions. RESULTS: CONCLUSION: This systematic review confirms the hypothesis of ciprofloxacin's noninferiority in the treatment of otitis externa, in terms of the cure rate and microbiological eradication.
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Authors | R Mösges, M Nematian-Samani, A Eichel |
Journal | Therapeutics and clinical risk management
(Ther Clin Risk Manag)
Vol. 7
Pg. 325-36
( 2011)
ISSN: 1178-203X [Electronic] New Zealand |
PMID | 21845055
(Publication Type: Journal Article)
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