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In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A.

Abstract
Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice. The volume of paw edema was reduced at 1h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1h after oral administration of urolithin A. These results indicate strong associations among plasma urolithin A levels, the plasma ORAC scores, and anti-inflammatory effects and may help explain a mechanism by which ellagitannins confer protection against inflammatory diseases.
AuthorsHidekazu Ishimoto, Mari Shibata, Yuki Myojin, Hideyuki Ito, Yukio Sugimoto, Akihiro Tai, Tsutomu Hatano
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 21 Issue 19 Pg. 5901-4 (Oct 01 2011) ISSN: 1464-3405 [Electronic] England
PMID21843938 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Ltd. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Coumarins
  • Free Radical Scavengers
  • Glucosides
  • Glucuronides
  • Hydrolyzable Tannins
  • ellagitannin
  • 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one
  • Geraniin
Topics
  • Administration, Oral
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, blood, pharmacology)
  • Antioxidants (administration & dosage, chemistry, metabolism, pharmacology)
  • Coumarins (administration & dosage, blood, pharmacology)
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Discovery
  • Drug Evaluation, Preclinical
  • Edema (chemically induced, drug therapy)
  • Free Radical Scavengers (analysis)
  • Glucosides
  • Glucuronides (metabolism)
  • Humans
  • Hydrolyzable Tannins (metabolism)
  • Lythraceae
  • Mice
  • Mice, Inbred ICR
  • Rats

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