GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis.

Abstract

PURPOSE:

Accumulating evidences implicate the selenium-containing cytosolic glutathione peroxidase, GPx-1, as a determinant of cancer risk and a mediator of the chemopreventive properties of selenium. Since the identification of a well-characterized functional polymorphism named Pro198Leu (rs1050450 C>T) in GPx-1, abundant studies have evaluated the association between Pro198Leu polymorphism and tumor risk in diverse population. But, the available results are conflicting.

METHODS:

To derive a more precise estimation, we performed a meta-analysis based on 14,372 cases with different tumor types and 18,081 controls from 31 published case-control studies. Published literature from PubMed was retrieved. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association.

RESULTS:

Overall, the results indicated that individuals who carried variant Leu allele (Pro/Leu and Leu/Leu) were associated with an increased cancer risk [odds ratio (OR) = 1.12, 95% confidence interval (CI) = 1.02-1.23] in a dominant genetic model. In further subgroup analyses, the increased risk of cancer was observed in subgroup of Asians and sample size more than 500 subjects.

CONCLUSION:

These results suggest that the GPx-1 Pro198Leo polymorphism contributes to cancer susceptibility through a disturbed antioxidant balance.

• Authors: Jiawei Chen, Qiang Cao, Chao Qin, Pengfei Shao, Yilong Wu, Meilin Wang, Zhengdong Zhang, Changjun Yin
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 137 Issue 10 Pg. 1553-61 (Oct 2011) ISSN: 1432-1335 [Electronic] Germany
• PMID: 21842217 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Glutathione Peroxidase
• Glutathione Peroxidase GPX1
• GPX1 protein, human

Topics

• Female
• Genetic Predisposition to Disease
• Glutathione Peroxidase (genetics, physiology)
• Humans
• Male
• Neoplasms (etiology, genetics)
• Polymorphism, Genetic
• Publication Bias
• Glutathione Peroxidase GPX1