Analgesic activity of aqueous leaf extract of Phyllanthus amarus.

Abstract

Various doses of the aqueous extract of Phyllanthus amarus (AEPA) were investigated for analgesic and anti-inflammatory activities using both thermal and chemical models of pain assessment in rats. The extract caused a significant (P < 0.05) dose related increase inhibition of the carrageenan-induced paw oedema in the rats. The inhibition produced by 200 mg/kg AEPA (70.20%) was significantly higher than that of the reference drug (Acetylsalicylic acid). The extract produced a marked analgesic activity by inhibiting both early and late phases of pain stimulus in Formalin-induced paw licking rats and also a significant and dose related increase in inhibiting the mean tail immersion duration (MITD) at varying water bath temperature (50 degrees C, 55 degrees C and 60 degrees C). This study thus established the anti-inflammatory and analgesic activities of Phyllanthus amarus.

• Authors: B O Iranloye, V B Owoyele, O R Kelani, S B Olaleye
• Journal: African journal of medicine and medical sciences (Afr J Med Med Sci) Vol. 40 Issue 1 Pg. 47-50 (Mar 2011) ISSN: 0309-3913 [Print] Nigeria
• PMID: 21834261 (Publication Type: Journal Article)

Chemical References

• Analgesics
• Anti-Inflammatory Agents
• Plant Extracts
• Water
• Carrageenan

Topics

• Analgesics (isolation & purification, pharmacology, therapeutic use)
• Animals
• Anti-Inflammatory Agents (isolation & purification, therapeutic use)
• Carrageenan
• Dose-Response Relationship, Drug
• Edema (chemically induced, drug therapy)
• Female
• Lethal Dose 50
• Male
• Mice
• Pain (drug therapy)
• Pain Measurement
• Phyllanthus (chemistry)
• Phytotherapy
• Plant Extracts (pharmacology, therapeutic use)
• Plant Leaves (chemistry)
• Rats
• Rats, Wistar
• Water