Abstract | OBJECTIVES: METHODS: the study was designed as a 1-month, double-blind, parallel, randomized clinical trial comparing a negative control regimen (minus active ingredients dentifrice and mouth rinse) with the test products ( dentifrice and mouth rinse with 0.05% CPC) in terms of plaque and gingival indexes (PI, GI), patient-based and microbiological outcome variables. The comparisons in relation to the main outcome variables (PI and GI) were made by means of the t-test, either unpaired or paired for the intergroup and intragroup comparisons, respectively. RESULTS: no differences were detected at baseline. Both groups showed statistically significant decreases in GI (0.17-0.19), without intergroup differences. The PI demonstrated a significant decrease of -0.12 in the test group and minor changes in the negative control group (increase of +0.01). Differences between groups showed a tendency towards statistical significance. A limited impact was observed for microbiological variables in both groups. CONCLUSION: the results of this study show limited benefits of the evaluated formulations as adjuncts to unsupervised oral hygiene in reducing plaque accumulation, and no effect on gingivitis.
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Authors | M Rioboo, V García, J Serrano, A O'Connor, D Herrera, M Sanz |
Journal | International journal of dental hygiene
(Int J Dent Hyg)
Vol. 10
Issue 2
Pg. 98-106
(May 2012)
ISSN: 1601-5037 [Electronic] England |
PMID | 21831254
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 John Wiley & Sons A/S. |
Chemical References |
- Anti-Infective Agents, Local
- Dentifrices
- Mouthwashes
- Cetylpyridinium
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Topics |
- Adult
- Anti-Infective Agents, Local
(therapeutic use)
- Bacteria
(drug effects)
- Cetylpyridinium
(therapeutic use)
- Colony Count, Microbial
- Combined Modality Therapy
- Dental Plaque
(drug therapy, microbiology, prevention & control)
- Dental Plaque Index
- Dentifrices
- Double-Blind Method
- Female
- Gingivitis
(drug therapy, microbiology, prevention & control)
- Humans
- Male
- Mouthwashes
- Periodontal Index
- Treatment Outcome
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