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Clinical and microbiological efficacy of an antimicrobial mouth rinse containing 0.05% cetylpyridinium chloride in patients with gingivitis.

AbstractOBJECTIVES:
the aim of this study was to evaluate the effects of the use of a mouth rinse and dentifrice with cetylpyridinium chloride (CPC) in patients with gingivitis.
METHODS:
the study was designed as a 1-month, double-blind, parallel, randomized clinical trial comparing a negative control regimen (minus active ingredients dentifrice and mouth rinse) with the test products (dentifrice and mouth rinse with 0.05% CPC) in terms of plaque and gingival indexes (PI, GI), patient-based and microbiological outcome variables. The comparisons in relation to the main outcome variables (PI and GI) were made by means of the t-test, either unpaired or paired for the intergroup and intragroup comparisons, respectively.
RESULTS:
no differences were detected at baseline. Both groups showed statistically significant decreases in GI (0.17-0.19), without intergroup differences. The PI demonstrated a significant decrease of -0.12 in the test group and minor changes in the negative control group (increase of +0.01). Differences between groups showed a tendency towards statistical significance. A limited impact was observed for microbiological variables in both groups.
CONCLUSION:
the results of this study show limited benefits of the evaluated formulations as adjuncts to unsupervised oral hygiene in reducing plaque accumulation, and no effect on gingivitis.
AuthorsM Rioboo, V García, J Serrano, A O'Connor, D Herrera, M Sanz
JournalInternational journal of dental hygiene (Int J Dent Hyg) Vol. 10 Issue 2 Pg. 98-106 (May 2012) ISSN: 1601-5037 [Electronic] England
PMID21831254 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Copyright© 2011 John Wiley & Sons A/S.
Chemical References
  • Anti-Infective Agents, Local
  • Dentifrices
  • Mouthwashes
  • Cetylpyridinium
Topics
  • Adult
  • Anti-Infective Agents, Local (therapeutic use)
  • Bacteria (drug effects)
  • Cetylpyridinium (therapeutic use)
  • Colony Count, Microbial
  • Combined Modality Therapy
  • Dental Plaque (drug therapy, microbiology, prevention & control)
  • Dental Plaque Index
  • Dentifrices
  • Double-Blind Method
  • Female
  • Gingivitis (drug therapy, microbiology, prevention & control)
  • Humans
  • Male
  • Mouthwashes
  • Periodontal Index
  • Treatment Outcome

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