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Conversional synthesis and cytotoxic evaluation of novel taxoid analogs.

Abstract
Four novel taxoid analogs were conversionally synthesized from the C(19)-diterpenoid alkaloid deltaline, and their cytotoxic activities were evaluated against a small panel of cancer cell lines.
AuthorsLei Song, Qiao-Hong Chen, Xue-Ke She, Xiao-Guang Chen, Feng-Peng Wang
JournalJournal of Asian natural products research (J Asian Nat Prod Res) Vol. 13 Issue 9 Pg. 787-98 (Sep 2011) ISSN: 1477-2213 [Electronic] England
PMID21830882 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Alkaloids
  • Antineoplastic Agents
  • Diterpenes
  • Taxoids
  • deltaline
  • Docetaxel
  • Paclitaxel
Topics
  • Alkaloids (chemistry)
  • Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
  • Diterpenes (chemistry)
  • Docetaxel
  • Drug Screening Assays, Antitumor
  • Humans
  • Molecular Structure
  • Paclitaxel (chemistry)
  • Taxoids (chemical synthesis, chemistry, pharmacology)

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