Abstract |
Agomelatine, an MT1/ MT2 receptor agonist and 5-HT2C receptor antagonist antidepressant, is known to have beneficial effects on subjective sleep in major depressive disorder patients. This international multicenter, randomized, double-blind study compared the effects of agomelatine (25-50 mg/day) and escitalopram (10-20 mg/day) on sleep polysomnographic parameters in major depressive disorder patients treated up to 24 weeks. A total of 138 outpatients were randomly allocated to agomelatine (n=71) or escitalopram (n=67). Treatment with agomelatine was associated with a reduction in sleep latency from week 2 onward. The difference between treatments was significant on all evaluations. Rapid eye movement latency was increased with escitalopram compared with agomelatine, with significant between-group differences at every visit. Agomelatine preserved the number of sleep cycles, whereas it was decreased with escitalopram with significant between-group differences at every visit. Assessments on visual analogue scales indicated that treatment with agomelatine improved morning condition, and reduced daytime sleepiness compared with escitalopram.17-item Hamilton depression rating scale total score was reduced in both groups, agomelatine was statistically noninferior to escitalopram at 6 weeks. Both treatments were well tolerated. This study showed that the clinical effects of agomelatine on sleep and wake parameters are different from that of escitalopram.
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Authors | Maria-Antonia Quera-Salva, Goeran Hajak, Pierre Philip, Jaques Montplaisir, Sophie Keufer-Le Gall, Judith Laredo, Christian Guilleminault |
Journal | International clinical psychopharmacology
(Int Clin Psychopharmacol)
Vol. 26
Issue 5
Pg. 252-62
(Sep 2011)
ISSN: 1473-5857 [Electronic] England |
PMID | 21829106
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acetamides
- Hypnotics and Sedatives
- Serotonin Uptake Inhibitors
- Citalopram
- agomelatine
- Melatonin
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Topics |
- Acetamides
(pharmacology, therapeutic use)
- Adult
- Citalopram
(pharmacology, therapeutic use)
- Depressive Disorder, Major
(drug therapy, psychology)
- Double-Blind Method
- Female
- Humans
- Hypnotics and Sedatives
(therapeutic use)
- Male
- Melatonin
(agonists)
- Middle Aged
- Polysomnography
(methods)
- Selective Serotonin Reuptake Inhibitors
(therapeutic use)
- Sleep Stages
(drug effects, physiology)
- Treatment Outcome
- Wakefulness
(drug effects, physiology)
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