Abstract | OBJECTIVE: METHODS: This study identified 27 single nucleotide polymorphisms (SNPs) in the exon, promoter, and exon-intron boundary regions of TGFBR3 by resequencing in 24 individuals. Then, 9 SNPs in the promoter and exons of the gene were genotyped from 1,065 Koreans composed of 637 chronic carriers (CC) and 428 spontaneously recovered (SR) subjects. RESULTS: Two SNPs, rs1805113 (Phe676Phe) in exon 13 and rs1805117 in 3'-UTR (p = 0.009 and p = 0.008, respectively) were significantly associated with HBV clearance. In addition, Cox relative hazards analyses revealed that haplotype BL2_ht2 showed a significant association with the age of HCC occurrence among chronic HBV patients (relative hazard = 1.38; p = 0.007). CONCLUSION: Our findings suggest that TGFBR3 polymorphisms and its haplotypes might be associated with HBV clearance and age of HCC occurrence.
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Authors | Jeong-Hyun Kim, Su Jong Yu, Byung-Lae Park, Hyun Sub Cheong, Charisse Flerida A Pasaje, Joon Seol Bae, Hyo-Suk Lee, Hyoung Doo Shin, Yoon Jun Kim |
Journal | Digestive diseases (Basel, Switzerland)
(Dig Dis)
Vol. 29
Issue 3
Pg. 278-83
( 2011)
ISSN: 1421-9875 [Electronic] Switzerland |
PMID | 21829018
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 S. Karger AG, Basel. |
Chemical References |
- Proteoglycans
- Receptors, Transforming Growth Factor beta
- betaglycan
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Topics |
- Adult
- Aging
(genetics)
- Carcinoma, Hepatocellular
(complications, epidemiology, genetics, virology)
- Female
- Genetic Predisposition to Disease
- Haplotypes
(genetics)
- Hepatitis B virus
(physiology)
- Hepatitis B, Chronic
(complications, genetics, virology)
- Humans
- Liver Neoplasms
(complications, epidemiology, genetics, virology)
- Male
- Middle Aged
- Physical Chromosome Mapping
- Polymorphism, Single Nucleotide
(genetics)
- Proteoglycans
(genetics)
- Receptors, Transforming Growth Factor beta
(genetics)
- Republic of Korea
(epidemiology)
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