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Toxic agents causing cerebellar ataxias.

Abstract
The cerebellum is particularly vulnerable to intoxication and poisoning, especially so the cerebellar cortex and Purkinje neurons. In humans, the most common cause of a toxic lesion to the cerebellar circuitry is alcohol related, but the cerebellum is also a main target of drug exposure (such as anticonvulsants, antineoplastics, lithium salts, calcineurin inhibitors), drug abuse and addiction (such as cocaine, heroin, phencyclidine), and environmental toxins (such as mercury, lead, manganese, toluene/benzene derivatives). Although data for the prevalence and incidence of cerebellar lesions related to intoxication and poisoning are still unknown in many cases, clinicians should keep in mind the list of agents that may cause cerebellar deficits, since toxin-induced cerebellar ataxias are not rare in daily practice. Moreover, the patient's status may require immediate therapies when the intoxication is life-threatening.
AuthorsMario Manto
JournalHandbook of clinical neurology (Handb Clin Neurol) Vol. 103 Pg. 201-13 ( 2012) ISSN: 0072-9752 [Print] Netherlands
PMID21827890 (Publication Type: Journal Article, Review)
Copyright2012 Elsevier B.V. All rights reserved.
Chemical References
  • Anticonvulsants
  • Antineoplastic Agents
  • Hazardous Substances
  • Neurotoxins
Topics
  • Anticonvulsants (toxicity)
  • Antineoplastic Agents (toxicity)
  • Cerebellar Ataxia (etiology)
  • Hazardous Substances (toxicity)
  • Humans
  • Neurotoxicity Syndromes (complications, etiology)
  • Neurotoxins (toxicity)

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