Abstract |
We made a prospective study using vaginal suppository of Géméprost (analogue of PGE1) and intravenous infusion of Sulprostone (analogue of PGE2) in thirty second- and third-trimesters pregnancy terminations. The efficacy was excellent for both procedures: only one failure, mean duration of abortion of 15 h 15 with Sulprostone, interval of 17 hours with Géméprost. In this case, the delay was shorter when vaginal administration was made every 6 hours. The evacuation of the uterus was very good, however one aspiration was made three days after abortion. Few side effects were observed with these two drugs: one case of fever, one case of vomiting, both with Sulprostone: two cases of nausea, one case of diarrhoea with Géméprost. We think that the effectiveness is marked and comparable, allowing the use of epidural anesthesia.
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Authors | P Poulain, J Blanchot, J M Roze, S Babatasi, J Y Grall |
Journal | Journal de gynecologie, obstetrique et biologie de la reproduction
(J Gynecol Obstet Biol Reprod (Paris))
Vol. 19
Issue 2
Pg. 223-7
( 1990)
ISSN: 0368-2315 [Print] France |
Vernacular Title | Utilisation comparée des analogues de prostaglandines en perfusion ou par ovules vaginaux dans les interruptions de grossesses. |
PMID | 2182703
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)
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Chemical References |
- Abortifacient Agents
- Abortifacient Agents, Nonsteroidal
- gemeprost
- sulprostone
- Alprostadil
- Dinoprostone
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Topics |
- Abortifacient Agents
(administration & dosage)
- Abortifacient Agents, Nonsteroidal
(administration & dosage, adverse effects, therapeutic use)
- Administration, Intravaginal
- Adult
- Alprostadil
(administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
- Clinical Trials as Topic
- Dinoprostone
(administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
- Female
- Fever
(chemically induced)
- Gastrointestinal Diseases
(chemically induced)
- Humans
- Infusions, Intravenous
- Pregnancy
- Prospective Studies
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