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[Comparative use of analogs of prostaglandin by intravenous or vaginal administration in termination of pregnancy].

Abstract
We made a prospective study using vaginal suppository of Géméprost (analogue of PGE1) and intravenous infusion of Sulprostone (analogue of PGE2) in thirty second- and third-trimesters pregnancy terminations. The efficacy was excellent for both procedures: only one failure, mean duration of abortion of 15 h 15 with Sulprostone, interval of 17 hours with Géméprost. In this case, the delay was shorter when vaginal administration was made every 6 hours. The evacuation of the uterus was very good, however one aspiration was made three days after abortion. Few side effects were observed with these two drugs: one case of fever, one case of vomiting, both with Sulprostone: two cases of nausea, one case of diarrhoea with Géméprost. We think that the effectiveness is marked and comparable, allowing the use of epidural anesthesia.
AuthorsP Poulain, J Blanchot, J M Roze, S Babatasi, J Y Grall
JournalJournal de gynecologie, obstetrique et biologie de la reproduction (J Gynecol Obstet Biol Reprod (Paris)) Vol. 19 Issue 2 Pg. 223-7 ( 1990) ISSN: 0368-2315 [Print] France
Vernacular TitleUtilisation comparée des analogues de prostaglandines en perfusion ou par ovules vaginaux dans les interruptions de grossesses.
PMID2182703 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Abortifacient Agents
  • Abortifacient Agents, Nonsteroidal
  • gemeprost
  • sulprostone
  • Alprostadil
  • Dinoprostone
Topics
  • Abortifacient Agents (administration & dosage)
  • Abortifacient Agents, Nonsteroidal (administration & dosage, adverse effects, therapeutic use)
  • Administration, Intravaginal
  • Adult
  • Alprostadil (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
  • Clinical Trials as Topic
  • Dinoprostone (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
  • Female
  • Fever (chemically induced)
  • Gastrointestinal Diseases (chemically induced)
  • Humans
  • Infusions, Intravenous
  • Pregnancy
  • Prospective Studies

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