Abstract |
Activation of self-reactive CD4(+) T cells plays a central role in the initiation and maintenance of autoimmune diseases. We recently reported that intravenous immunoglobulin ( IVIg) inhibits the MHC II-restricted CD4(+) T cell activation induced by the presentation of immune complexes. Because native antigens can also play a role in the induction of several autoimmune diseases, we determined whether IVIg could also affect CD4(+) T cell activation following presentation of native antigens by APCs. Here we report that IVIg significantly reduces the activation of CD4(+) T cells by native ovalbumin. The inhibitory effect is FcγR-independent and occurs following internalization of IVIg inside APCs, where it interferes with the intracellular events leading to MHC II-dependent antigen presentation. The effect of IVIg on native antigen presentation could therefore contribute to dampen the autoimmune reaction by reducing CD4(+) T cell activation and the subsequent inflammatory response induced by these cells.
|
Authors | Éric Aubin, Dominic Paquin Proulx, Patrick Trépanier, Réal Lemieux, Renée Bazin |
Journal | Clinical immunology (Orlando, Fla.)
(Clin Immunol)
Vol. 141
Issue 3
Pg. 273-83
(Dec 2011)
ISSN: 1521-7035 [Electronic] United States |
PMID | 21824820
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Histocompatibility Antigens Class II
- Immunoglobulins, Intravenous
- Ovalbumin
|
Topics |
- Animals
- Antigen Presentation
(immunology)
- CD4-Positive T-Lymphocytes
(immunology)
- Cell Line
- Dendritic Cells
(immunology)
- Female
- Histocompatibility Antigens Class II
(immunology)
- Immunoglobulins, Intravenous
(immunology, pharmacology)
- Lymphocyte Activation
(drug effects, immunology)
- Macrophages
(immunology)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred CBA
- Ovalbumin
(immunology)
|