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Prevention of T cell activation by interference of internalized intravenous immunoglobulin (IVIg) with MHC II-dependent native antigen presentation.

Abstract
Activation of self-reactive CD4(+) T cells plays a central role in the initiation and maintenance of autoimmune diseases. We recently reported that intravenous immunoglobulin (IVIg) inhibits the MHC II-restricted CD4(+) T cell activation induced by the presentation of immune complexes. Because native antigens can also play a role in the induction of several autoimmune diseases, we determined whether IVIg could also affect CD4(+) T cell activation following presentation of native antigens by APCs. Here we report that IVIg significantly reduces the activation of CD4(+) T cells by native ovalbumin. The inhibitory effect is FcγR-independent and occurs following internalization of IVIg inside APCs, where it interferes with the intracellular events leading to MHC II-dependent antigen presentation. The effect of IVIg on native antigen presentation could therefore contribute to dampen the autoimmune reaction by reducing CD4(+) T cell activation and the subsequent inflammatory response induced by these cells.
AuthorsÉric Aubin, Dominic Paquin Proulx, Patrick Trépanier, Réal Lemieux, Renée Bazin
JournalClinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 141 Issue 3 Pg. 273-83 (Dec 2011) ISSN: 1521-7035 [Electronic] United States
PMID21824820 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Inc. All rights reserved.
Chemical References
  • Histocompatibility Antigens Class II
  • Immunoglobulins, Intravenous
  • Ovalbumin
Topics
  • Animals
  • Antigen Presentation (immunology)
  • CD4-Positive T-Lymphocytes (immunology)
  • Cell Line
  • Dendritic Cells (immunology)
  • Female
  • Histocompatibility Antigens Class II (immunology)
  • Immunoglobulins, Intravenous (immunology, pharmacology)
  • Lymphocyte Activation (drug effects, immunology)
  • Macrophages (immunology)
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred CBA
  • Ovalbumin (immunology)

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