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Expression of fatty acid synthase (FASN) in oral nevi and melanoma.

AbstractOBJECTIVE:
The aim of this study was to determine the expression of fatty acid synthase (FASN) in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions.
MATERIALS AND METHODS:
Expression of FASN was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas, in 10 cutaneous nevi and in 14 melanomas.
RESULTS:
Fatty acid synthase was strongly expressed only in melanomas, either of the oral mucosa or cutaneous. On the other hand, most oral and cutaneous nevi were negative, with a few oral cases showing focal and weak expression.
CONCLUSION:
Fatty acid synthase is expressed in malignant melanocytes, and it can be a helpful marker to distinguish oral melanomas from oral melanocytic nevi.
AuthorsB A B de Andrade, J E León, R Carlos, W Delgado-Azañero, A Mosqueda-Taylor, E Graner, O P de Almeida
JournalOral diseases (Oral Dis) Vol. 17 Issue 8 Pg. 808-12 (Nov 2011) ISSN: 1601-0825 [Electronic] Denmark
PMID21819495 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2011 John Wiley & Sons A/S.
Chemical References
  • Antibodies
  • Biomarkers, Tumor
  • Coloring Agents
  • Fatty Acid Synthases
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies
  • Biomarkers, Tumor (analysis)
  • Coloring Agents
  • Fatty Acid Synthases (analysis)
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Melanocytes (enzymology)
  • Melanoma (enzymology)
  • Middle Aged
  • Mouth Mucosa (enzymology)
  • Mouth Neoplasms (enzymology)
  • Nevus (enzymology)
  • Nevus, Intradermal (enzymology)
  • Nevus, Pigmented (enzymology)
  • Skin Neoplasms (enzymology)
  • Young Adult

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