Atmospheric identification of active ingredients in over-the-counter pharmaceuticals and drugs of abuse by atmospheric pressure glow discharge mass spectrometry (APGD-MS).

Abstract

Atmospheric pressure glow discharge mass spectrometry was used to characterize the active ingredients in pharmaceutical over-the-counter (OTC) drug formulations (Tylenol Allergy, Alka-Seltzer Plus Nighttime, Sudafed, Aleve and Mucinex DM) and drugs of abuse (crack cocaine, methamphetamine, MDMA (ecstasy) and hydrocodone). Material was desorbed and directly ionized under atmospheric conditions by allowing the substance to come in direct contact with the plasma followed by mass spectrometric detection. With this technique, controlled substances and OTC medications were readily distinguished from one another. Characteristic mass spectra were identified for the active ingredients in the OTC and drugs of abuse. Importantly, all drug compounds studied here, both OTC and illicit, demonstrated signals for either molecular ions or protonated molecules as well as fragmentation patterns that are readily identified in the National Institute of Standards and Technology (NIST) electron ionization (EI) mass spectral library. It is believed that this technique holds promise for forensic and law enforcement communities for real-time atmospheric analysis of drugs with database-searchable spectra of controlled substances.

• Authors: Tim M Brewer, Jennifer R Verkouteren
• Journal: Rapid communications in mass spectrometry : RCM (Rapid Commun Mass Spectrom) Vol. 25 Issue 17 Pg. 2407-17 (Sep 15 2011) ISSN: 1097-0231 [Electronic] England
• PMID: 21818799 (Publication Type: Journal Article)
• Copyright: Published in 2011 by John Wiley & Sons, Ltd.

Chemical References

• Illicit Drugs
• Nonprescription Drugs
• Plasma Gases

Topics

• Atmospheric Pressure
• Databases, Factual
• Forensic Toxicology
• Illicit Drugs (analysis, chemistry)
• Mass Spectrometry (methods)
• Nonprescription Drugs (analysis, chemistry)
• Plasma Gases