Clinical efficacy of colesevelam in type 2 diabetes mellitus.

Abstract

PURPOSE:

The clinical experience and role in therapy of colesevelam in type 2 diabetes mellitus (T2DM) is discussed.

SUMMARY:

Colesevelam HCl is a bile acid sequestrant (BAS) with proven efficacy in reducing elevated low-density lipoprotein cholesterol (LDL-C) in patients with primary hyperlipidemia. Colesevelam HCl gained food and drug administration (FDA) approval in 2008 as an adjunct to diet and exercise to improve glycemic control in adults with T2DM. In randomized controlled studies, colesevelam (add-on therapy with metformin, sulfonylureas, and insulin) has shown significant percentage reductions in glycosylated hemoglobin A1c (HbA1c) ranging from 0.5% to 0.54%. Reductions in LDL-C and non-high-density lipoprotein cholesterol (non-HDL-C) ranging from -12.8% to -16.7% and -4.0% to -10.3%, respectively, were also observed. Although no direct comparisons have been made, the safety and tolerability profile of this agent appears to be better than other BAS, with the most common side effects being gastrointestinal related.

CONCLUSION:

Colesevelam is effective as an adjunct to diet and exercise to improve glycemic control in adults with T2DM. Due to its effects upon LDL-C and glycemic parameters and favorable safety profile, colesevelam can play a role in an array of T2DM patients.

• Authors: Luigi Brunetti, R Keith Campbell
• Journal: Journal of pharmacy practice (J Pharm Pract) Vol. 24 Issue 4 Pg. 417-25 (Aug 2011) ISSN: 1531-1937 [Electronic] United States
• PMID: 21813819 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Anticholesteremic Agents
• Allylamine
• Colesevelam Hydrochloride

Topics

• Allylamine (analogs & derivatives, therapeutic use)
• Anticholesteremic Agents (therapeutic use)
• Colesevelam Hydrochloride
• Diabetes Mellitus, Type 2 (drug therapy)
• Humans
• Hypercholesterolemia (drug therapy)
• Randomized Controlled Trials as Topic