Abstract | PURPOSE: METHODS: RESULTS: Compared with controls, both OPG (p = 0.023) and sRANKL (p = 0.010) serum levels were increased in men with late-onset hypogonadism; however, when expressed as a ratio, sRANKL/OPG, the two groups were not significantly different. Simple and age-adjusted analyses showed that OPG was inversely related to FT and positively related to SHBG, E2 and BAP. In the patient population, LH demonstrated statistically significant correlations with both OPG (r = 0.274, p = 0.013) and sRANKL (r = 0.276, p = 0.018). Multiple regression analysis retained age, SHBG, E2 and BAP as independent predictors of OPG, explaining 27.71% of serum OPG variability. CONCLUSIONS: Late-onset hypogonadism is associated with enhanced RANKL activity. Increased bone turnover-related OPG levels may act as a coupling factor between bone resorption and formation. The results suggest anti-RANKL-agents as therapeutic tools in osteoporotic men with late-onset hypogonadism.
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Authors | Carmen E Pepene, Nicolae Crişan, Ioan Coman |
Journal | Clinical and investigative medicine. Medecine clinique et experimentale
(Clin Invest Med)
Vol. 34
Issue 4
Pg. E232
(Aug 01 2011)
ISSN: 1488-2353 [Electronic] Canada |
PMID | 21810381
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Osteoprotegerin
- RANK Ligand
- Sex Hormone-Binding Globulin
- Testosterone
- Estradiol
- Follicle Stimulating Hormone
|
Topics |
- Age of Onset
- Aged
- Enzyme-Linked Immunosorbent Assay
- Estradiol
(blood)
- Follicle Stimulating Hormone
(blood)
- Humans
- Hypogonadism
(blood)
- Male
- Osteoprotegerin
(blood)
- RANK Ligand
(blood)
- Sex Hormone-Binding Globulin
(metabolism)
- Testosterone
(blood)
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