Abstract | AIMS: MAIN METHODS: KEY FINDINGS: The macroscopic lesion score of the colitis group was reduced by SIL (p < 0.01) and this effect was abolished by l-NAME (p < 0.01). Increase in colonic MDA along with a concomitant decrease in GSH of the colitis group was reversed by SIL (p < 0.01 and p < 0.001, respectively). l-NAME prevented the effect of SIL on GSH content (p < 0.001). Sildenafil also reduced the elevated MPO of the colitis group (p < 0.001) and this effect was reversed by L-NAME (p < 0.01). Increase in lucigenin CL and serum TNF-α levels in the colitis group were also prevented by SIL (p < 0.001 and p < 0.01, respectively). SIGNIFICANCE:
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Authors | Berna Karakoyun, Unal Uslu, Feriha Ercan, Mehmet Serif Aydin, Meral Yuksel, Ayliz Velioglu Ogunc, Inci Alican |
Journal | Life sciences
(Life Sci)
Vol. 89
Issue 11-12
Pg. 402-7
(Sep 12 2011)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 21806998
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Phosphodiesterase 5 Inhibitors
- Piperazines
- Purines
- Reactive Oxygen Species
- Sulfones
- Tumor Necrosis Factor-alpha
- Interleukin-10
- Malondialdehyde
- Trinitrobenzenesulfonic Acid
- Sildenafil Citrate
- Peroxidase
- Glutathione
- NG-Nitroarginine Methyl Ester
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Topics |
- Animals
- Apoptosis
(drug effects)
- Colitis
(chemically induced, drug therapy, metabolism, pathology)
- Female
- Glutathione
(analysis)
- Inflammatory Bowel Diseases
(chemically induced, drug therapy, metabolism, pathology)
- Interleukin-10
(metabolism)
- Male
- Malondialdehyde
(metabolism)
- NG-Nitroarginine Methyl Ester
(pharmacology)
- Peroxidase
(metabolism)
- Phosphodiesterase 5 Inhibitors
(pharmacology)
- Piperazines
(pharmacology)
- Purines
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Reactive Oxygen Species
(metabolism)
- Sildenafil Citrate
- Sulfones
(pharmacology)
- Trinitrobenzenesulfonic Acid
- Tumor Necrosis Factor-alpha
(metabolism)
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