Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine.

Abstract

In a previous dose escalation study our group found that combining 90μg/kg rFVIIa with HBOC-201 reduced blood loss and improved physiologic parameters compared to HBOC alone. In this follow-up study in a swine liver injury model, we found that while there were no adverse hematology effects and trends observed in the previous study were confirmed, statistical significance could not be reached. Additional pre-clinical studies are indicated to identify optimal components of a multifunctional blood substitute for clinical use in trauma.

• Authors: Ashraful Haque, Françoise Arnaud, Kohsuke Teranishi, Tomoaki Okada, Bobby Kim, Paula F Moon-Massat, Charles Auker, Richard McCarron, Daniel Freilich, Anke H Scultetus
• Journal: Artificial cells, blood substitutes, and immobilization biotechnology (Artif Cells Blood Substit Immobil Biotechnol) Vol. 40 Issue 1-2 Pg. 44-55 (Feb 2012) ISSN: 1532-4184 [Electronic] England
• PMID: 21806503 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Blood Substitutes
• Hemoglobins
• Recombinant Proteins
• HBOC 201
• Factor VIIa
• Oxygen

Topics

• Animals
• Blood Substitutes (pharmacology)
• Blood Volume (drug effects)
• Drug Interactions
• Factor VIIa (pharmacology, therapeutic use)
• Female
• Fluid Therapy (methods)
• Hemoglobins (pharmacology, therapeutic use)
• Hospitals
• Male
• Oxygen (metabolism)
• Recombinant Proteins (pharmacology, therapeutic use)
• Shock, Hemorrhagic (drug therapy, metabolism, pathology, physiopathology)
• Survival Analysis
• Swine