Abstract | INTRODUCTION: METHODS: Animals were divided into 12 groups (4 matrix types and 3 termination time-points per matrix). A ventral defect was carefully created and overlapped with the biologic prosthesis. RESULTS: Major complications were seroma induction (3 mesh types), implant extrusion (1 mesh type), severe inflammatory and immune responses (non-crosslinked mesh), fibrosis and mineralisation (3 mesh types). After inflammation resolution, 3 of the matrices tested supported hernia healing but with marked tissue and temporal differences. AlloDerm(®*) and Surgisis Gold™ showed tissue reactivity with the host and a rapid rate of matrix remodelling. Bard CollaMend™(*) Implant proved to be inept for hernia repair under the conditions tested. Permacol™ biological implant integration with host tissue increased over time, supporting hernia healing with strength of tissue, and appears to be a safe prosthetic material for ventral hernia repair based on the results of this rodent study.
|
Authors | L E de Castro Brás, S Shurey, P D Sibbons |
Journal | Hernia : the journal of hernias and abdominal wall surgery
(Hernia)
Vol. 16
Issue 1
Pg. 77-89
(Feb 2012)
ISSN: 1248-9204 [Electronic] France |
PMID | 21805341
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Alloderm
- Biocompatible Materials
- Permacol
- Collagen
|
Topics |
- Abdominal Wall
(pathology)
- Animals
- Biocompatible Materials
(adverse effects)
- Collagen
(adverse effects, therapeutic use)
- Fibrosis
- Hernia, Ventral
(surgery)
- Herniorrhaphy
(adverse effects)
- Inflammation
(etiology, pathology)
- Male
- Materials Testing
- Prosthesis Failure
- Rats
- Rats, Sprague-Dawley
- Seroma
(etiology)
- Surgical Mesh
(adverse effects)
- Tensile Strength
- Time Factors
|