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Biotransformation of a taxadiene by ginkgo cell cultures and the tumor multi-drug resistant reversal activities of the metabolites.

Abstract
The biotransformation of 2α,5α,10β-triacetoxy-14-oxo-taxa-4(20),11-diene (1) by cultured Gingko cells afforded four products. Their structures were identified on the basis of analyses of the chemical and spectroscopic (IR, MS, ¹H- and ¹³C-NMR) data. Among them, 2, 3 and 5 were three new compounds, and 4 displayed potent multi-drug resistant (MDR) reversal activities to MX-1/T tumor MDR cells.
AuthorsDan Xie, Yi Zhang, Jianhua Zou, Dali Yin, Xiaoguang Chen, Jungui Dai
JournalChemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 59 Issue 8 Pg. 1038-41 ( 2011) ISSN: 1347-5223 [Electronic] Japan
PMID21804250 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Alkenes
  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • taxa-4(5),11(12)diene
  • Paclitaxel
Topics
  • Alkenes (chemistry, metabolism, pharmacology)
  • Antineoplastic Agents, Phytogenic (pharmacology)
  • Biotransformation
  • Cell Line, Tumor
  • Cells, Cultured
  • Diterpenes (chemistry, metabolism, pharmacology)
  • Drug Resistance, Multiple (drug effects)
  • Drug Resistance, Neoplasm (drug effects)
  • Ginkgo biloba (cytology, metabolism)
  • Humans
  • Paclitaxel (pharmacology)

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