Biotransformation of a taxadiene by ginkgo cell cultures and the tumor multi-drug resistant reversal activities of the metabolites.

Abstract

The biotransformation of 2α,5α,10β-triacetoxy-14-oxo-taxa-4(20),11-diene (1) by cultured Gingko cells afforded four products. Their structures were identified on the basis of analyses of the chemical and spectroscopic (IR, MS, ¹H- and ¹³C-NMR) data. Among them, 2, 3 and 5 were three new compounds, and 4 displayed potent multi-drug resistant (MDR) reversal activities to MX-1/T tumor MDR cells.

• Authors: Dan Xie, Yi Zhang, Jianhua Zou, Dali Yin, Xiaoguang Chen, Jungui Dai
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 59 Issue 8 Pg. 1038-41 ( 2011) ISSN: 1347-5223 [Electronic] Japan
• PMID: 21804250 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkenes
• Antineoplastic Agents, Phytogenic
• Diterpenes
• taxa-4(5),11(12)diene
• Paclitaxel

Topics

• Alkenes (chemistry, metabolism, pharmacology)
• Antineoplastic Agents, Phytogenic (pharmacology)
• Biotransformation
• Cell Line, Tumor
• Cells, Cultured
• Diterpenes (chemistry, metabolism, pharmacology)
• Drug Resistance, Multiple (drug effects)
• Drug Resistance, Neoplasm (drug effects)
• Ginkgo biloba (cytology, metabolism)
• Humans
• Paclitaxel (pharmacology)