Biotransformation of a taxadiene by ginkgo cell cultures and the tumor multi-drug resistant reversal activities of the metabolites.

The biotransformation of 2α,5α,10β-triacetoxy-14-oxo-taxa-4(20),11-diene (1) by cultured Gingko cells afforded four products. Their structures were identified on the basis of analyses of the chemical and spectroscopic (IR, MS, ¹H- and ¹³C-NMR) data. Among them, 2, 3 and 5 were three new compounds, and 4 displayed potent multi-drug resistant (MDR) reversal activities to MX-1/T tumor MDR cells.
AuthorsDan Xie, Yi Zhang, Jianhua Zou, Dali Yin, Xiaoguang Chen, Jungui Dai
JournalChemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 59 Issue 8 Pg. 1038-41 ( 2011) ISSN: 1347-5223 [Electronic] Japan
PMID21804250 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Alkenes
  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • taxa-4(5),11(12)diene
  • Paclitaxel
  • Alkenes (chemistry, metabolism, pharmacology)
  • Antineoplastic Agents, Phytogenic (pharmacology)
  • Biotransformation
  • Cell Line, Tumor
  • Cells, Cultured
  • Diterpenes (chemistry, metabolism, pharmacology)
  • Drug Resistance, Multiple (drug effects)
  • Drug Resistance, Neoplasm (drug effects)
  • Ginkgo biloba (cytology, metabolism)
  • Humans
  • Paclitaxel (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: