Impact of dose-dense immunochemotherapy on prognosis of germinal center and non germinal center origin of diffuse large B cell lymphoma.

Abstract	Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. Gene-expression profiling in DLCBL has brought insight into the biological heterogeneity of the disease. Two major subgroups have been identified: germinal center B (GCB) cell and non-germinal center (non-GCB). The aim of this study was to define retrospectively by immunohistochemistry the bcell origin of 69 patients treated with R-CHOP14 and to evaluate if dose-dense therapy could improve their clinical outcome. According to immunohistochemistry analysis 28 patients were derived from germinal center and 41 from non-germinal center. After a median period of observation of 46 months (range 3-101 months) the overall survival (OS) was 75% and progression-free survival (PFS) was 53% and no differences were observed according to cell origin. In conclusion, we can point out that intensification could enhance the efficacy of the R-CHOP regimen and improve overall survival in patients with non germinal lymphoma.
Authors	L Rigacci, B Puccini, L Iovino, M Martelli, E Finolezzi, S DI Lollo, M Doria, A Bosi
Journal	Journal of chemotherapy (Florence, Italy) (J Chemother) Vol. 23 Issue 4 Pg. 227-31 (Aug 2011) ISSN: 1973-9478 [Electronic] England
PMID	21803701 (Publication Type: Journal Article)
Chemical References	Antibodies, Monoclonal, Murine-Derived Antineoplastic Agents Rituximab Vincristine Doxorubicin Cyclophosphamide Prednisone
Topics	Adult Aged Antibodies, Monoclonal, Murine-Derived (administration & dosage) Antineoplastic Agents (administration & dosage) Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use) B-Lymphocytes (drug effects, pathology) Cyclophosphamide (administration & dosage) Disease-Free Survival Doxorubicin (administration & dosage) Female Germinal Center (pathology) Humans Immunohistochemistry (methods) Lymphoma, Large B-Cell, Diffuse (drug therapy, pathology) Male Middle Aged Prednisone (administration & dosage) Prognosis Retrospective Studies Rituximab Treatment Outcome Vincristine (administration & dosage)

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