Abstract | PURPOSE OF INVESTIGATION: METHODS AND RESULTS: Transfection of DAPK small-interfering RNAs (siRNAs) into the HHUA cells reduced DAPK protein expression, and enhanced Fas-mediated apoptosis, in a dose-dependent manner. CONCLUSIONS: These results indicate that, in contrast to cases with other malignant tumor cells, DAPK negatively regulates Fas-mediated apoptosis in these human differentiated endometrial adenocarcinoma cells.
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Authors | T Tanaka, T Bai, K Yukawa |
Journal | European journal of gynaecological oncology
(Eur J Gynaecol Oncol)
Vol. 32
Issue 3
Pg. 293-6
( 2011)
ISSN: 0392-2936 [Print] Singapore |
PMID | 21797120
(Publication Type: Journal Article)
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Chemical References |
- Apoptosis Regulatory Proteins
- FAS protein, human
- RNA, Small Interfering
- fas Receptor
- Death-Associated Protein Kinases
- Calcium-Calmodulin-Dependent Protein Kinases
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Topics |
- Apoptosis
(physiology)
- Apoptosis Regulatory Proteins
(genetics, metabolism)
- Blotting, Western
- Calcium-Calmodulin-Dependent Protein Kinases
(genetics, metabolism)
- Cell Count
- Cell Line, Tumor
- Cell Survival
- Death-Associated Protein Kinases
- Down-Regulation
- Humans
- RNA, Small Interfering
- Transfection
- fas Receptor
(genetics, metabolism)
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