Fludrocortisone improves nausea in children with orthostatic intolerance (OI).

Abstract

UNLABELLED:

INTRODUCTION/RESULTS: In 17 patients, chronic idiopathic nausea was associated with orthostatic intolerance (OI) by abnormal tilt table tests (88%) or gastric dysrhythmias (71%). After fludrocortisone treatment, there was >26% nausea improvement in 71%, 1-25% in 6%, and no improvement in 24%. In six subjects, EGGs repeated after >50% nausea improvement all remained to be abnormal, suggesting nausea is independent of gastric dysrhythmias.

CONCLUSION:

Association of EGG abnormalities and OI in this subset of nausea patients suggests a generalized disturbance of autonomic regulation.

• Authors: John E Fortunato, Hossam A Shaltout, Megan M Larkin, Peter C Rowe, Debra I Diz, Kenneth L Koch
• Journal: Clinical autonomic research : official journal of the Clinical Autonomic Research Society (Clin Auton Res) Vol. 21 Issue 6 Pg. 419-23 (Dec 2011) ISSN: 1619-1560 [Electronic] Germany
• PMID: 21796356 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Fludrocortisone

Topics

• Adolescent
• Anti-Inflammatory Agents (therapeutic use)
• Child
• Female
• Fludrocortisone (therapeutic use)
• Humans
• Male
• Nausea (complications, drug therapy)
• Orthostatic Intolerance (complications)
• Retrospective Studies