Abstract | OBJECTIVE: METHODS: We addressed the kinetics of anti-MOG immunoglobulins in a prospective study comprising 77 pediatric patients. This was supplemented by a cross-sectional study analyzing 126 pediatric patients with acute demyelination and 62 adult patients with multiple sclerosis (MS). MOG-transfected cells were used for detection of antibodies by flow cytometry. RESULTS: Twenty-five children who were anti-MOG immunoglobulin (Ig) positive at disease onset were followed for up to 5 years. Anti-MOG antibodies rapidly and continuously declined in all 16 monophasic patients with acute disseminated encephalomyelitis and in one patient with clinically isolated syndrome. In contrast, in 6 of 8 patients (75%) eventually diagnosed with childhood MS, the antibodies to MOG persisted with fluctuations showing a second increase during an observation period of up to 5 years. Antibodies to MOG were mainly IgG 1 and their binding was largely blocked by pathogenic anti-MOG antibodies derived from a spontaneous animal model of autoimmune encephalitis. The cross-sectional part of our study elaborated that anti-MOG Ig was present in about 25% of children with acute demyelination, but in none of the pediatric or adult controls. Sera from 4/62 (6%) adult patients with MS had anti-MOG IgG at low levels. CONCLUSIONS: The persistence or disappearance of antibodies to MOG may have prognostic relevance for acute childhood demyelination.
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Authors | A K Pröbstel, K Dornmair, R Bittner, P Sperl, D Jenne, S Magalhaes, A Villalobos, C Breithaupt, R Weissert, U Jacob, M Krumbholz, T Kuempfel, A Blaschek, W Stark, J Gärtner, D Pohl, K Rostasy, F Weber, I Forne, M Khademi, T Olsson, F Brilot, E Tantsis, R C Dale, H Wekerle, R Hohlfeld, B Banwell, A Bar-Or, E Meinl, T Derfuss |
Journal | Neurology
(Neurology)
Vol. 77
Issue 6
Pg. 580-8
(Aug 09 2011)
ISSN: 1526-632X [Electronic] United States |
PMID | 21795651
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Immunoglobulin G
- Immunoglobulins
- MOG protein, human
- Myelin Proteins
- Myelin-Associated Glycoprotein
- Myelin-Oligodendrocyte Glycoprotein
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Topics |
- Adolescent
- Adult
- Autoantibodies
(analysis)
- Binding, Competitive
- Cell Line
- Child
- Child, Preschool
- Cohort Studies
- Cross-Sectional Studies
- Encephalomyelitis, Acute Disseminated
(immunology)
- Female
- Flow Cytometry
- Humans
- Immunoglobulin G
(analysis)
- Immunoglobulins
(analysis)
- Infant
- Kinetics
- Longitudinal Studies
- Male
- Multiple Sclerosis
(immunology, metabolism)
- Myelin Proteins
- Myelin-Associated Glycoprotein
(immunology)
- Myelin-Oligodendrocyte Glycoprotein
- Prospective Studies
- Transfection
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