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Aortic dissecting aneurysms--histopathological findings.

Abstract
Acute aortic dissection is a life-threatening disease with a high rate of mortality. At the Institute of Legal Medicine of the Hanover Medical School, 30 cases with aortic dissections were found during autopsy and examined histologically between 2006 and 2009. The grade of medial alterations in the form of cystic medial necrosis, elastin fragmentation, fibrosis and medionecrosis were estimated semi-quantitatively. In order to assess the normal aging process, samples of the aortic wall of 25 decedents without dissecting aneurysms were analyzed histologically. This study demonstrates that there are partly quantitative differences, particularly with a statistically significant increase in cystic medial necrosis (p<0.001) and elastin fragmentation (p<0.001), between aortas from dissecting aneurysms and the normal aging aorta, which may help to identify genetically predisposed relatives of patients with a dissection of the aorta.
AuthorsS Bode-Jänisch, A Schmidt, D Günther, M Stuhrmann, A Fieguth
JournalForensic science international (Forensic Sci Int) Vol. 214 Issue 1-3 Pg. 13-7 (Jan 10 2012) ISSN: 1872-6283 [Electronic] Ireland
PMID21794994 (Publication Type: Journal Article)
CopyrightCopyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Elastin
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging (pathology)
  • Aortic Dissection (pathology)
  • Aorta (metabolism, pathology)
  • Aortic Aneurysm (pathology)
  • Arteriosclerosis (pathology)
  • Case-Control Studies
  • Elastin (metabolism)
  • Female
  • Fibrosis
  • Forensic Pathology
  • Humans
  • Male
  • Middle Aged
  • Necrosis
  • Tunica Media (pathology)

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