Abstract |
We reported the efficacy of topical cutaneous N-acetylcysteine in children with type I lamellar ichthyosis. The drug was applied on predetermined body surface areas two times a day for 6 weeks, followed by a daily maintenance application. During the first 2 weeks of treatment, a significant improvement occurred. After 4 months of maintenance application, a marked overall improvement occurred in all the treated areas. Only two patients showed mild adverse effects such as light burning, pruritus, and irritation. Even though a larger group of patients should be necessary to confirm the data, topical 10% N-acetylcysteine emulsion prepared in urea 5% seems to be a valuable and safe therapeutic option for lamellar ichthyosis in children, with benefit not only for skin lesions but also for ectropion avoiding a surgical procedure.
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Authors | Adriana Bassotti, Silvia Moreno, Elena Criado |
Journal | Pediatric dermatology
(Pediatr Dermatol)
2011 Jul-Aug
Vol. 28
Issue 4
Pg. 451-5
ISSN: 1525-1470 [Electronic] United States |
PMID | 21793884
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2011 Wiley Periodicals, Inc. |
Chemical References |
- Dermatologic Agents
- Urea
- Acetylcysteine
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Topics |
- Acetylcysteine
(adverse effects, therapeutic use)
- Adolescent
- Child
- Child, Preschool
- Dermatologic Agents
(adverse effects, therapeutic use)
- Female
- Humans
- Ichthyosis, Lamellar
(drug therapy)
- Infant
- Male
- Pruritus
(chemically induced)
- Treatment Outcome
- Urea
(administration & dosage)
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