Abstract | BACKGROUND: OBJECTIVES: To determine whether the PDE5 inhibitor, zaprinast, causes dilation in pulmonary and middle cerebral arteries (MCA) of normoxic newborn piglets and those with chronic hypoxia-induced pulmonary hypertension, and to evaluate whether zaprinast alters responses to increased pressure (autoregulatory ability) of the MCA. METHODS: Two-day-old piglets were raised in normoxia or hypoxia for 3 or 10 days. Pulmonary arteries and MCA were isolated and pressurized, after which changes in diameter to zaprinast were measured. MCA pressure-diameter relationships were determined. RESULTS: Dilation to zaprinast was similar in pulmonary arteries from normoxic and hypoxic piglets. Zaprinast dilated MCA from all groups but the response was diminished in MCA from piglets raised in hypoxia for 10 days. MCA pressure-diameter relationships (autoregulation) did not differ between the groups. CONCLUSIONS:
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Authors | Candice D Fike, Mark Kaplowitz, Yongmei Zhang, Mark Dantuma, Jane A Madden |
Journal | Neonatology
(Neonatology)
Vol. 101
Issue 1
Pg. 28-39
( 2012)
ISSN: 1661-7819 [Electronic] Switzerland |
PMID | 21791937
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2011 S. Karger AG, Basel. |
Chemical References |
- Phosphodiesterase Inhibitors
- Purinones
- 3',5'-Cyclic-AMP Phosphodiesterases
- zaprinast
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Topics |
- 3',5'-Cyclic-AMP Phosphodiesterases
(antagonists & inhibitors, metabolism)
- Animals
- Animals, Newborn
- Chronic Disease
- Disease Models, Animal
- Hypertension, Pulmonary
(drug therapy, etiology)
- Hypoxia
(complications)
- Middle Cerebral Artery
(drug effects, physiopathology)
- Phosphodiesterase Inhibitors
(pharmacology)
- Pulmonary Artery
(drug effects, physiopathology)
- Purinones
(pharmacology)
- Swine
- Vasodilation
(drug effects)
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