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Cantharidin-podophylotoxin-salicylic acid versus cryotherapy in the treatment of plantar warts: a randomized prospective study.

AbstractBACKGROUND:
Plantar warts are refractory to any form of treatment. High cure rates have been reported with a topical proprietary formulation consisting of 1% cantharidin, 5% podophyllotoxin and 30% salicylic acid (CPS). However, no data exists comparing the efficacy of this formulation with another treatment. Cryotherapy is a method that is also widely used in the treatment of plantar warts. Likewise, there is no evidence that it is more effective than any topical treatment.
OBJECTIVE:
We aim to compare the efficacy of topical CPS and cryotherapy in the treatment of plantar warts.
METHODS:
Patients with plantar warts were consecutively treated with either cryotherapy or topical CPS. Both treatments were performed every 2 weeks for up to five sessions. In patients without complete clearance, the therapy was switched to the other treatment option.
RESULTS:
Twenty-six patients with a total of 134 warts were included. Fourteen patients were completely cleared of their warts with topical CPS, whereas only in five of 12 patients (41.7%) warts were completely cleared with cryotherapy (P=0.001). In seven patients without complete clearance, the therapy was switched to CPS. Four of these patients missed the follow-up. While the two of the remaining three patients were cleared of their warts, one patient's warts still failed to clear.
CONCLUSION:
Topical CPS is more effective than cryotherapy in the treatment of plantar warts.
AuthorsN Kaçar, L Taşlı, S Korkmaz, S Ergin, B Ş Erdoğan
JournalJournal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 26 Issue 7 Pg. 889-93 (Jul 2012) ISSN: 1468-3083 [Electronic] England
PMID21790794 (Publication Type: Journal Article, Randomized Controlled Trial)
Copyright© 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology.
Chemical References
  • Cantharidin
  • Podophyllotoxin
  • Salicylic Acid
Topics
  • Adolescent
  • Adult
  • Cantharidin (administration & dosage, therapeutic use)
  • Combined Modality Therapy
  • Cryotherapy
  • Female
  • Foot
  • Humans
  • Male
  • Podophyllotoxin (administration & dosage, therapeutic use)
  • Prospective Studies
  • Salicylic Acid (administration & dosage, therapeutic use)
  • Warts (drug therapy)
  • Young Adult

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