Abstract | BACKGROUND: Plantar warts are refractory to any form of treatment. High cure rates have been reported with a topical proprietary formulation consisting of 1% cantharidin, 5% podophyllotoxin and 30% salicylic acid (CPS). However, no data exists comparing the efficacy of this formulation with another treatment. Cryotherapy is a method that is also widely used in the treatment of plantar warts. Likewise, there is no evidence that it is more effective than any topical treatment. OBJECTIVE: We aim to compare the efficacy of topical CPS and cryotherapy in the treatment of plantar warts. METHODS: Patients with plantar warts were consecutively treated with either cryotherapy or topical CPS. Both treatments were performed every 2 weeks for up to five sessions. In patients without complete clearance, the therapy was switched to the other treatment option. RESULTS: Twenty-six patients with a total of 134 warts were included. Fourteen patients were completely cleared of their warts with topical CPS, whereas only in five of 12 patients (41.7%) warts were completely cleared with cryotherapy (P=0.001). In seven patients without complete clearance, the therapy was switched to CPS. Four of these patients missed the follow-up. While the two of the remaining three patients were cleared of their warts, one patient's warts still failed to clear. CONCLUSION: Topical CPS is more effective than cryotherapy in the treatment of plantar warts.
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Authors | N Kaçar, L Taşlı, S Korkmaz, S Ergin, B Ş Erdoğan |
Journal | Journal of the European Academy of Dermatology and Venereology : JEADV
(J Eur Acad Dermatol Venereol)
Vol. 26
Issue 7
Pg. 889-93
(Jul 2012)
ISSN: 1468-3083 [Electronic] England |
PMID | 21790794
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | © 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology. |
Chemical References |
- Cantharidin
- Podophyllotoxin
- Salicylic Acid
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Topics |
- Adolescent
- Adult
- Cantharidin
(administration & dosage, therapeutic use)
- Combined Modality Therapy
- Cryotherapy
- Female
- Foot
- Humans
- Male
- Podophyllotoxin
(administration & dosage, therapeutic use)
- Prospective Studies
- Salicylic Acid
(administration & dosage, therapeutic use)
- Warts
(drug therapy)
- Young Adult
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