Abstract | BACKGROUND: STUDY DESIGN AND METHODS: We retrospectively identified and reviewed the records of pediatric liver or combined liver and small bowel transplant patients with both serologic and clinical evidence of AIHA. We also performed an English language literature review for prior publications of AIHA occurring after solid organ transplantation. RESULTS: CONCLUSION: AIHA may occur in solid organ transplant patients at a much higher frequency than previously believed. Hemolysis is often severe and resistant to steroid treatment alone. Thus early diagnosis and institution of aggressive multimodality treatment, including the use of rituximab, may be needed to achieve remission.
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Authors | Marissa Li, Dennis Goldfinger, Shan Yuan |
Journal | Transfusion
(Transfusion)
Vol. 52
Issue 1
Pg. 48-54
(Jan 2012)
ISSN: 1537-2995 [Electronic] United States |
PMID | 21790626
(Publication Type: Journal Article, Review)
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Copyright | © 2011 American Association of Blood Banks. |
Chemical References |
- Immunosuppressive Agents
- Steroids
- Tacrolimus
|
Topics |
- Adolescent
- Anemia, Hemolytic, Autoimmune
(diagnosis, drug therapy)
- Female
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Infant
- Liver Transplantation
(adverse effects)
- Male
- Organ Transplantation
(adverse effects)
- Steroids
(therapeutic use)
- Tacrolimus
(therapeutic use)
|