Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition.

Abstract

BACKGROUND:

Insulin-like growth factor-1 (IGF-I) is important in normal brain development but in the adult brain, IGF-I overexpression may be a risk factor for tumor development.

METHODS:

We examined the association between circulating concentrations of IGF-I and IGFBP-3 in relation to risk of gliomas (74 low-grade, 206 high-grade gliomas), meningiomas (n = 174) and acoustic neuromas (n = 49) by using a case-control design nested in the European Prospective Investigation into Cancer and Nutrition. IGF-I and IGFBP-3 were measured by ELISAs.Conditional logistic regression was used to compute ORs and corresponding 95% CIs.

RESULTS:

The risk of low-grade gliomas was elevated with increased IGF-I (OR = 3.60, 95% CI: 1.11-11.7; top vs. bottom quartile) and decreased with elevated IGFBP-3 concentrations (OR = 0.28, 95% CI: 0.09-0.84) after mutual adjustment of these two factors; these results became nonsignificant after exclusion of the first year of follow-up. No association was observed for high-grade gliomas or meningiomas. Both high IGF-I and IGFBP-3 concentrations were associated with risk of acoustic neuromas (IGF-I: OR = 6.63, 95% CI: 2.27-19.4, top vs. bottom tertile; IGFBP-3: OR = 7.07, 95% CI: 2.32-21.6), even after excluding the first year of follow-up.

CONCLUSION:

High concentrations of IGF-I might be positively associated with risk of low-grade gliomas and acoustic neuromas, although we cannot exclude reverse causation, in particular for low-grade gliomas.

IMPACT:

Factors of the IGF axis might be involved in the etiology of some types of brain tumors.

• Authors: Sabine Rohrmann, Jakob Linseisen, Susen Becker, Naomi Allen, Brigitte Schlehofer, Kim Overvad, Anja Olsen, Anne Tjønneland, Beatrice S Melin, Eiliv Lund, Paolo Vineis, Sara Grioni, Rosario Tumino, Domenico Palli, Amalia Mattiello, Catalina Bonet, Maria-Dolores Chirlaque, María-José Sánchez, Laudina Rodríguez, Miren Dorronsoro, Eva Ardanaz, Pagona Lagiou, Antonia Trichopoulou, Dimitrios Trichopoulos, Laure Dossus, Verena A Grote, Heiner Boeing, Krasimira Aleksandrova, H Bas Bueno-de-Mesquita, Fränzel J B van Duijnhoven, Petra H M Peeters, Kay-Tee Khaw, Nicholas J Wareham, Timothy J Key, Sabina Rinaldi, Isabelle Romieux, Valentina Gallo, Dominique S Michaud, Elio Riboli, Rudolf Kaaks
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 20 Issue 10 Pg. 2174-82 (Oct 2011) ISSN: 1538-7755 [Electronic] United States
• PMID: 21788435 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: ©2011 AACR

Chemical References

• Biomarkers, Tumor
• IGFBP3 protein, human
• Insulin-Like Growth Factor Binding Protein 3
• Insulin-Like Growth Factor I

Topics

• Biomarkers, Tumor (metabolism)
• Brain Neoplasms (etiology, metabolism, pathology)
• Case-Control Studies
• Cohort Studies
• Enzyme-Linked Immunosorbent Assay
• Female
• Follow-Up Studies
• Glioma (etiology, metabolism, pathology)
• Humans
• Insulin-Like Growth Factor Binding Protein 3 (metabolism)
• Insulin-Like Growth Factor I (metabolism)
• Male
• Meningeal Neoplasms (etiology, metabolism, pathology)
• Middle Aged
• Neuroma, Acoustic (etiology, metabolism, pathology)
• Nutritional Status
• Prognosis
• Prospective Studies