Effect of epoxides and α-methylene-γ-lactone skeleton of sesquiterpenes from yacon (Smallanthus sonchifolius) leaves on caspase-dependent apoptosis and NF-κB inhibition in human cercival cancer cells.

Abstract

The present study investigated the cytotoxicity of enhydrin (1), uvedalin (2) and sonchifolin (3) in cervical cancer cells. We have found that SLs 1-3 in doses in range of 0.22-10 μM inhibited cell proliferation and induced apoptosis in both a dose- and time-dependent fashion. A significant cell death induction was supported by morphological studies. The apoptotic effect is associated with caspase-3/7 activation and NF-кB inhibition. Interestingly, enhydrin possessing two epoxide units was found to be the most cytotoxic compound. Therefore it can be assumed that number of epoxides and existence of α-methylene-γ-lactone moiety are essential for the acceleration of apoptosis.

• Authors: Dalad Siriwan, Takayuki Naruse, Hirotoshi Tamura
• Journal: Fitoterapia (Fitoterapia) Vol. 82 Issue 7 Pg. 1093-101 (Oct 2011) ISSN: 1873-6971 [Electronic] Netherlands
• PMID: 21787849 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier B.V. All rights reserved.

Chemical References

• Antineoplastic Agents, Phytogenic
• Epoxy Compounds
• Lactones
• NF-kappa B
• Plant Extracts
• Sesquiterpenes
• enhydrin
• methylene-lactone
• Caspase 3
• Caspase 7

Topics

• Antineoplastic Agents, Phytogenic (pharmacology, therapeutic use)
• Apoptosis (drug effects)
• Asteraceae (chemistry)
• Caspase 3 (metabolism)
• Caspase 7 (metabolism)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Dose-Response Relationship, Drug
• Epoxy Compounds (pharmacology, therapeutic use)
• Female
• Humans
• Lactones (pharmacology, therapeutic use)
• NF-kappa B (antagonists & inhibitors)
• Phytotherapy
• Plant Extracts (pharmacology, therapeutic use)
• Plant Leaves
• Sesquiterpenes (therapeutic use)
• Uterine Cervical Neoplasms (drug therapy, metabolism)