The mitochondrial citrate carrier: a new player in inflammation.

Abstract

The mitochondrial CIC (citrate carrier) catalyses the efflux of citrate from the mitochondrial matrix in exchange for cytosolic malate. In the present paper we show that CIC mRNA and protein markedly increase in lipopolysaccharide-activated immune cells. Moreover, CIC gene silencing and CIC activity inhibition significantly reduce production of NO, reactive oxygen species and prostaglandins. These results demonstrate for the first time that CIC has a critical role in inflammation.

• Authors: Vittoria Infantino, Paolo Convertini, Liana Cucci, Maria Antonietta Panaro, Maria Antonietta Di Noia, Rosa Calvello, Ferdinando Palmieri, Vito Iacobazzi
• Journal: The Biochemical journal (Biochem J) Vol. 438 Issue 3 Pg. 433-6 (Sep 15 2011) ISSN: 1470-8728 [Electronic] England
• PMID: 21787310 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carrier Proteins
• Inflammation Mediators
• Mitochondrial Proteins
• RNA, Messenger
• citrate-binding transport protein
• Nitric Oxide

Topics

• Carrier Proteins (antagonists & inhibitors, genetics, physiology)
• Cells, Cultured
• Cytosol (metabolism)
• Gene Silencing
• Humans
• Inflammation Mediators (metabolism)
• Mitochondria (metabolism)
• Mitochondrial Proteins (antagonists & inhibitors, genetics, physiology)
• Nitric Oxide (metabolism)
• RNA, Messenger (metabolism)
• Up-Regulation