Advanced cancer of the extremities treated by cryosurgery.

Abstract

AIM:

Cryosurgery with liquid nitrogen (LN) is a safe and effective method to treat skin cancer. With the correct protocol, its efficacy is extended to advanced and inoperable tumors. The aim of this study was to report the author's experience in the treatment of advanced squamous-cell carcinomas of the extremities.

METHODS:

Forty-eight patients (31 women and 17 men; mean age of 79 years) with 50 advanced squamous-cell carcinomas (SCC) of the extremities were treated with open and thick LN spray--two freeze-thaw cycles--reaching a temperature around -50 ºC inside the tumor, but not less than -20 ºC in the tumor limits and the underlying structures. Temperature monitoring was made by thermocouples. All cases in this series were treated by the author.

RESULTS:

The overall cure rate was 88%, with follow-up between 1 and 8 years (mean of 2.64 years).

CONCLUSION:

This cryosurgical method is an effective treatment for advanced cancers of the extremities, yielding a high cure rate and, in many cases, preventing amputation.

• Authors: J C Almeida Gonçalves
• Journal: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia (G Ital Dermatol Venereol) Vol. 146 Issue 4 Pg. 249-55 (Aug 2011) ISSN: 0392-0488 [Print] Italy
• PMID: 21785390 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Nitrogen

Topics

• Carcinoma, Squamous Cell (pathology, surgery)
• Cryosurgery (methods)
• Esthetics
• Extremities (surgery)
• Female
• Follow-Up Studies
• Humans
• Male
• Neoplasm Invasiveness
• Nitrogen (therapeutic use)
• Postoperative Complications (etiology)
• Retrospective Studies
• Skin Neoplasms (pathology, surgery)
• Skin Ulcer (etiology)
• Treatment Outcome