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Expression of N-myc downstream regulated gene 1 (NDRG1) in central neurocytoma.

Abstract
N-myc downstream regulated gene 1 (NDRG1), also known as Cap43, Drg-1, and rit42, is expressed in various normal tissues and cancers, in which it is often associated with a favorable prognosis. It also plays a critical role in central nervous system development, with NDRG1 deficiency resulting in neural defects in mice. Central neurocytoma (CN) is a relatively rare tumor of the neurocytes in the brain, which occurs mainly in young adults. In the present study, we found that tissue samples from four patients with CN had both nuclear and cytoplasmic/membranous expression of NDRG1 protein in highly differentiated CN tumor cells. NDRG1 was also expressed in intratumoral microvessels. Immunohistochemical study of serial sections from the same patients revealed a marked association between the expression pattern of NDRG1 and that of neuron-specific enolase, a tumor differentiation marker. The data presented in this study suggest that NDRG1 could be considered a potential differentiation marker for CN.
AuthorsAbbas Fotovati, Samah Abu-Ali, Yasuo Sugita, Yasuhiro Nakamura
JournalJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci) Vol. 18 Issue 10 Pg. 1383-5 (Oct 2011) ISSN: 1532-2653 [Electronic] Scotland
PMID21784644 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Ltd. All rights reserved.
Chemical References
  • Biomarkers, Tumor
  • Cell Cycle Proteins
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • N-myc downstream-regulated gene 1 protein
Topics
  • Animals
  • Biomarkers, Tumor (biosynthesis, genetics)
  • Cell Cycle Proteins (biosynthesis, genetics)
  • Cell Differentiation (genetics)
  • Cell Nucleus (genetics, metabolism, pathology)
  • Cytoplasm (genetics, metabolism, pathology)
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Intracellular Signaling Peptides and Proteins (genetics)
  • Membrane Proteins (biosynthesis, genetics)
  • Mice
  • Neurocytoma (genetics, metabolism, pathology)
  • Young Adult

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