Abstract | BACKGROUND: SCOPE OF REVIEW: MAJOR CONCLUSIONS: GENERAL SIGNIFICANCE: TGR may have differing functions in host organisms, but through analyses to understand its ability to reduce both glutathione and thioredoxin we can better understand the reaction mechanisms of an important class of enzymes. The unique properties of TGR in parasitic flatworms provide promising routes to develop new treatments for diseases.
|
Authors | Stefanie Prast-Nielsen, Hsin-Hung Huang, David L Williams |
Journal | Biochimica et biophysica acta
(Biochim Biophys Acta)
Vol. 1810
Issue 12
Pg. 1262-71
(Dec 2011)
ISSN: 0006-3002 [Print] Netherlands |
PMID | 21782895
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
|
Copyright | 2011 Elsevier B.V. All rights reserved. |
Chemical References |
- Multienzyme Complexes
- NADH, NADPH Oxidoreductases
- thioredoxin glutathione reductase
|
Topics |
- Animals
- Humans
- Multienzyme Complexes
(metabolism)
- NADH, NADPH Oxidoreductases
(metabolism)
- Oxidation-Reduction
|