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Synthesis and characterization of pH-dependent glycol chitosan and dextran sulfate nanoparticles for effective brain cancer treatment.

Abstract
A novel drug delivery system for the treatment of brain tumors was formulated by methotrexate (MTX)-loaded polymeric nanoparticles (NPs) based on Glycol chitosan (GCS) and Dextran sulfate (DS). The physicochemical properties of resulting particles were investigated, evidencing the contribution of these nanoparticles for brain targeting. In vitro release of MTX was also evaluated. The GCS-DS nanoparticles have been developed based on the modulation of ratio show promise as a system for controlled delivery of the drug to the brain.
AuthorsMohammad Reza Saboktakin, Roya M Tabatabaie, Abel Maharramov, Mohammad Ali Ramazanov
JournalInternational journal of biological macromolecules (Int J Biol Macromol) Vol. 49 Issue 4 Pg. 747-51 (Nov 01 2011) ISSN: 1879-0003 [Electronic] Netherlands
PMID21782844 (Publication Type: Journal Article)
CopyrightCopyright © 2011 Elsevier B.V. All rights reserved.
Chemical References
  • glycol-chitosan
  • Chitosan
  • Dextran Sulfate
  • Methotrexate
Topics
  • Brain Neoplasms (drug therapy)
  • Chitosan (chemical synthesis, chemistry)
  • Dextran Sulfate (chemical synthesis)
  • Drug Compounding
  • Hydrogen-Ion Concentration
  • Methotrexate (therapeutic use)
  • Molecular Weight
  • Nanoparticles (chemistry, ultrastructure)
  • Temperature

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