Abstract | PURPOSE: SETTING: Vienna Institute for Research in Ocular Surgery, Department of Ophthalmology, Hanusch Hospital, Vienna, Austria. DESIGN: Prospective randomized controlled study. METHODS: This randomized controlled subject- and examiner-masked study comprised patients scheduled for cataract surgery. The patients were randomly assigned to receive either BSS or hydroxypropyl methylcellulose (HPMC) 2% gel (Cornea_Protect). Fluorescein staining, optical clarity during surgery, application frequency, subjective grading of discomfort, and subjective dryness of the eye were assessed. RESULTS: One hundred one eyes of 97 patients (mean age 73.6 years; range 53 to 87 years) were included in the study. Mean grade of fluorescein staining was 9.46 ± 3.64 (SD) and 9.76 ± 3.27 (SD) in the BSS group and the HPMC 2% group, respectively (P=.67). Median grade of optical clarity during surgery was 2.0 in the BSS group and 1.0 in the HPMC 2% group, a statistically significant difference (P=.03). Median application frequency of BSS was 10 times higher than median application frequency of 1 time for HPMC 2%, a statistically significant difference (P<.001). CONCLUSIONS:
Hydroxypropyl methylcellulose 2% provided significantly better optical clarity than BSS during cataract surgery. Because frequent irrigation is not needed and HPMC 2% provides a better view for the surgeon, the use of HPMC 2% results in increased comfort for the patient, especially under topical anaesthesia, and in a simpler and possibly safer surgical procedure. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned. Additional disclosure is found in the footnotes.
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Authors | Yen-An Chen, Nino Hirnschall, Oliver Findl |
Journal | Journal of cataract and refractive surgery
(J Cataract Refract Surg)
Vol. 37
Issue 10
Pg. 1806-8
(Oct 2011)
ISSN: 1873-4502 [Electronic] United States |
PMID | 21782381
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Acetates
- BSS solution
- Drug Combinations
- Lubricants
- Minerals
- Ophthalmic Solutions
- Wetting Agents
- Hypromellose Derivatives
- Sodium Chloride
- Methylcellulose
- Fluorescein
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Topics |
- Acetates
(administration & dosage)
- Aged
- Aged, 80 and over
- Cataract Extraction
- Double-Blind Method
- Drug Combinations
- Epithelium, Corneal
(drug effects, physiology)
- Fluorescein
- Humans
- Hypromellose Derivatives
- Lubricants
- Methylcellulose
(administration & dosage, analogs & derivatives)
- Middle Aged
- Minerals
(administration & dosage)
- Ophthalmic Solutions
(administration & dosage)
- Prospective Studies
- Refraction, Ocular
(physiology)
- Sodium Chloride
(administration & dosage)
- Staining and Labeling
(methods)
- Wettability
- Wetting Agents
(administration & dosage)
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