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Comparison of corneal wetting properties of viscous eye lubricant and balanced salt solution to maintain optical clarity during cataract surgery.

AbstractPURPOSE:
To compare the corneal wetting properties of balanced salt solution (BSS) and a viscous eye lubricant during cataract surgery.
SETTING:
Vienna Institute for Research in Ocular Surgery, Department of Ophthalmology, Hanusch Hospital, Vienna, Austria.
DESIGN:
Prospective randomized controlled study.
METHODS:
This randomized controlled subject- and examiner-masked study comprised patients scheduled for cataract surgery. The patients were randomly assigned to receive either BSS or hydroxypropyl methylcellulose (HPMC) 2% gel (Cornea_Protect). Fluorescein staining, optical clarity during surgery, application frequency, subjective grading of discomfort, and subjective dryness of the eye were assessed.
RESULTS:
One hundred one eyes of 97 patients (mean age 73.6 years; range 53 to 87 years) were included in the study. Mean grade of fluorescein staining was 9.46 ± 3.64 (SD) and 9.76 ± 3.27 (SD) in the BSS group and the HPMC 2% group, respectively (P=.67). Median grade of optical clarity during surgery was 2.0 in the BSS group and 1.0 in the HPMC 2% group, a statistically significant difference (P=.03). Median application frequency of BSS was 10 times higher than median application frequency of 1 time for HPMC 2%, a statistically significant difference (P<.001).
CONCLUSIONS:
Hydroxypropyl methylcellulose 2% provided significantly better optical clarity than BSS during cataract surgery. Because frequent irrigation is not needed and HPMC 2% provides a better view for the surgeon, the use of HPMC 2% results in increased comfort for the patient, especially under topical anaesthesia, and in a simpler and possibly safer surgical procedure.
FINANCIAL DISCLOSURE:
No author has a financial or proprietary interest in any material or method mentioned. Additional disclosure is found in the footnotes.
AuthorsYen-An Chen, Nino Hirnschall, Oliver Findl
JournalJournal of cataract and refractive surgery (J Cataract Refract Surg) Vol. 37 Issue 10 Pg. 1806-8 (Oct 2011) ISSN: 1873-4502 [Electronic] United States
PMID21782381 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Acetates
  • BSS solution
  • Drug Combinations
  • Lubricants
  • Minerals
  • Ophthalmic Solutions
  • Wetting Agents
  • Hypromellose Derivatives
  • Sodium Chloride
  • Methylcellulose
  • Fluorescein
Topics
  • Acetates (administration & dosage)
  • Aged
  • Aged, 80 and over
  • Cataract Extraction
  • Double-Blind Method
  • Drug Combinations
  • Epithelium, Corneal (drug effects, physiology)
  • Fluorescein
  • Humans
  • Hypromellose Derivatives
  • Lubricants
  • Methylcellulose (administration & dosage, analogs & derivatives)
  • Middle Aged
  • Minerals (administration & dosage)
  • Ophthalmic Solutions (administration & dosage)
  • Prospective Studies
  • Refraction, Ocular (physiology)
  • Sodium Chloride (administration & dosage)
  • Staining and Labeling (methods)
  • Wettability
  • Wetting Agents (administration & dosage)

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