['ASIA' - Autoimmune/inflammatory syndrome induced by adjuvants: even and odd].

Abstract

Recently, Shoenfeld and Agmon-Levin described a potential new syndrome, namely ASIA - autoimmune/inflammatory syndrome induced by adjuvants, that comprises four medical conditions: siliconosis, the Gulf war syndrome, the macrophagic myofasciitis syndrome and post-vaccination phenomena, characterized by hyperactive immune responses accompanied by a similar complex of signs and symptoms. Most relevantly, these conditions share a linkage represented by adjuvants. This common soil may possibly induce autoimmune or auto-inflammatory diseases in humans as it was demonstrated in different animal models. Reconsidering under a unified umbrella this apparently detached condition is not only intriguing, but also provocative, and may help in unraveling novel pathogenetic mechanisms, preventive measures, and therapeutic targets.

• Authors: C Perricone, C Alessandri, G Valesini
• Journal: Reumatismo (Reumatismo) Vol. 63 Issue 2 Pg. 63-6 ( 2011) ISSN: 0048-7449 [Print] Italy
• Vernacular Title: 'SAIA' - Sindrome autoimmune/infiammatoria indotta da adiuvanti: presente e futuro.
• PMID: 21776441 (Publication Type: Editorial, English Abstract)

Chemical References

• Adjuvants, Immunologic
• Autoantibodies
• Environmental Pollutants
• Silicones

Topics

• Adjuvants, Immunologic (adverse effects)
• Animals
• Autoantibodies (blood, immunology)
• Autoimmune Diseases (chemically induced, immunology)
• Environmental Exposure
• Environmental Pollutants (adverse effects, immunology)
• Fasciitis (chemically induced, immunology)
• Humans
• Inflammation (chemically induced, immunology)
• Myositis (chemically induced, immunology)
• Persian Gulf Syndrome (chemically induced, immunology)
• Prostheses and Implants (adverse effects)
• Silicones (adverse effects)
• Syndrome
• Vaccination (adverse effects)