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Beta-adrenergic sensitivity in Parkinson's disease: effect of levodopa treatment.

Abstract
The beta-adrenergic sensitivity in never-treated and levodopa-treated patients with Parkinson's disease (PD) was studied through the evaluation of lymphocyte beta-adrenoceptor number ([125I]cyanopindolol binding sites) and chronotropic and metabolic (plasma nonesterified fatty acids--NEFA) responses to isoproterenol. No change was found in Bmax values or affinity constant Kd between never-treated patients, levodopa-treated patients with PD, and controls. At rest, no difference was observed in heart rate, plasma catecholamine, or NEFA levels between the three groups. Isoproterenol sensitivity (chronotropic response and plasma NEFA increase) was similar in never-treated and treated PD. The results suggest that peripheral beta-adrenergic sensitivity is unaffected either by the pathophysiological process of PD or by levodopa treatment.
AuthorsG Durrieu, Y Rispail, E Chatelut, M Berlan, A Rascol, J L Montastruc, P Montastruc
JournalClinical neuropharmacology (Clin Neuropharmacol) Vol. 13 Issue 6 Pg. 492-9 (Dec 1990) ISSN: 0362-5664 [Print] United States
PMID2177376 (Publication Type: Journal Article)
Chemical References
  • Fatty Acids, Nonesterified
  • Receptors, Adrenergic, beta
  • Levodopa
  • Isoproterenol
  • Norepinephrine
  • Epinephrine
Topics
  • Aged
  • Dose-Response Relationship, Drug
  • Epinephrine (blood)
  • Fatty Acids, Nonesterified (blood)
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Isoproterenol (pharmacology)
  • Kinetics
  • Levodopa (therapeutic use)
  • Lymphocytes (chemistry)
  • Male
  • Middle Aged
  • Norepinephrine (blood)
  • Parkinson Disease (blood, drug therapy, physiopathology)
  • Radioligand Assay
  • Receptors, Adrenergic, beta (drug effects)

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