Abstract | BACKGROUND: METHODS: Intraocular tropicamide of 0.005% concentration was administered in 3 groups: Alzheimer's disease patients (n = 8, average age = 76 ± 5), non- Alzheimer's disease elderly (n = 6, average age = 65 ± 7), and young subjects (n = 8, average age = 28 ± 5). Every 5 minutes for 60 minutes, image of the eye's shape were taken, and the diameter of the pupils was measured. RESULTS: The results showed that differences in pupil dilation rate between Alzheimer's disease and non- Alzheimer's disease subjects were statistically significant. ROC analysis showed that after 35 minutes the sensitivity and specificity of the test were 100%. CONCLUSIONS: Based on our results, we concluded that this recording system might be an appropriate and reliable tool for pupil response diagnosis test of Alzheimer's disease.
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Authors | Massoud Mahmoudian, Soltan Ahmed Ebrahimi, Zahra Kiani |
Journal | Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
(J Res Med Sci)
Vol. 14
Issue 4
Pg. 205-9
(Jul 2009)
ISSN: 1735-1995 [Print] India |
PMID | 21772885
(Publication Type: Journal Article)
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