A case of Crohn's disease with improvement after azathioprine-induced pancytopenia.

The immunosuppressant azathioprine (AZA) is widely used in the treatment of inflammatory bowel disease (IBD) for both inducing and maintaining remission. However, the adverse effects of AZA can often necessitate a dose reduction or discontinuation. Bone marrow suppression is one of the most serious complications with AZA treatment. On the other hand, some reports have suggested that neutropenia during AZA therapy reduced the relapse rates of IBD patients, and there have been some cases where eradication of the sensitized leukocytes by leukapheresis or bone marrow transplantation improved the IBD, which may explain the relevant role of neutropenia in controlling disease activity. This report describes the case of a 22-year-old male patient who had Crohn's colitis and complicated perianal fistulas that required immunosuppression; he achieved endoscopically determined remission and showed accelerated mucosal healing as well as clinical remission following the AZA-induced pancytopenia.
AuthorsYong Sung Choi, Jung Pil Suh, Kee Ho Song, Jae Bum Lee, Doo Seok Lee, In Taek Lee, Do Sun Kim, Doo Han Lee
JournalCase reports in gastroenterology (Case Rep Gastroenterol) Vol. 5 Issue 2 Pg. 344-9 ( 2011) ISSN: 1662-0631 [Electronic] Switzerland
PMID21769285 (Publication Type: Journal Article)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: