Abstract | PURPOSE: To assess the feasibility of using diffusion-weighted magnetic resonance (MR) imaging (DWI) for evaluating perianal fistula activity. MATERIALS AND METHODS: This study retrospectively assessed 24 patients with clinically suspected perianal fistula who underwent a total of 28 MR examinations after conservative treatment with antibiotics. DWI was performed at 1.5 T, using b-values of 0 and 1000 s/mm(2). Apparent diffusion coefficient (ADC) maps were created and ADCs of the lesions were measured. Lesions were classified into two groups based on the need for surgery and surgical findings: positive inflammation activity (PIA) and negative inflammation activity (NIA). ADCs of both groups were compared using an unpaired t-test, and Receiver Operating Characteristic (ROC) analysis was performed. RESULTS: The ADC (in 10(-3) mm(2)/s) of the PIA group (0.908±0.171) was significantly lower (P=0.0019) than that of the NIA group (1.124±0.244). The area under the ROC curve was 0.749. An optimal cut-off ADC of 1.109 yielded a sensitivity of 95.7%, a specificity of 50%, a positive predictive value of 71%, and a negative predictive value of 90%. CONCLUSION: DWI is a feasible method for evaluating perianal fistula activity. The diagnostic performance of this technique should be established in future, larger prospective studies.
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Authors | Takeshi Yoshizako, Akihiko Wada, Taro Takahara, Thomas C Kwee, Megumi Nakamura, Koji Uchida, Shinji Hara, Peter R Luijten, Hajime Kitagaki |
Journal | European journal of radiology
(Eur J Radiol)
Vol. 81
Issue 9
Pg. 2049-53
(Sep 2012)
ISSN: 1872-7727 [Electronic] Ireland |
PMID | 21767926
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Topics |
- Adult
- Aged
- Anal Canal
(abnormalities, pathology)
- Diffusion Magnetic Resonance Imaging
(methods)
- Feasibility Studies
- Female
- Humans
- Intestinal Fistula
(pathology)
- Male
- Middle Aged
- Reproducibility of Results
- Sensitivity and Specificity
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