Effect of sodium stibogluconate on the status of interleukin-I production in normal & Leishmania donovani infected BALB/c mice.

Abstract

Sodium stibogluconate, did not bring about significant increase in the production of IL-1, when both specific leishmanial antigen, or non specific Staphylococcus epidermidis was used as stimulus in normal uninfected animals. However, Staph. epidermidis was found to be a better stimulus as it brought about a significant increase (P less than 0.001) in IL-1 production when compared with leishmania antigen. In BALB/c mice infected with L. donovani there was a significant reduction (P less than 0.001) in IL-1 levels on various post infection days irrespective whether Staph. epidermidis or leishmanial antigen was used as stimulus when compared with controls. IL-1 levels were significantly increased (P less than 0.05) when L. donovani infected animals were treated with SSG, after 14 days post infection, irrespective of the stimuli used.

• Authors: S Sodhi, N K Ganguly, N Malla, R C Mahajan
• Journal: The Indian journal of medical research (Indian J Med Res) Vol. 91 Pg. 344-8 (Sep 1990) ISSN: 0971-5916 [Print] India
• PMID: 2176646 (Publication Type: Journal Article)

Chemical References

• Interleukin-1
• Antimony Sodium Gluconate

Topics

• Animals
• Antimony Sodium Gluconate (pharmacology)
• Female
• Interleukin-1 (biosynthesis)
• Leishmaniasis, Visceral (immunology)
• Male
• Mice
• Mice, Inbred BALB C
• Staphylococcus epidermidis (immunology)