HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Suppression of dust mite extract and 2,4-dinitrochlorobenzene-induced atopic dermatitis by the water extract of Lindera obtusiloba.

AbstractETHNOPHARMACOLOGICAL RELEVANCE:
The Lindera obtusiloba has been used in traditional medicine for the treatment of inflammation and dermatitis. In this study, we investigated the effect of topical application of Lindera obtusiloba water extract (LOWE) on the house dust mite extract (Dermatophagoides farinae extract, DFE) and 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD).
MATERIALS AND METHODS:
We established AD model in BALB/c mice by repeated local exposure of DFE/DNCB to the ears. After a topical application of LOWE on the skin lesions, the epidermal thickness, mast cell infiltration, and serum immunoglobulin E (IgE) and histamine were measured. In addition, the gene expression of interleukin (IL)-4, IL-13, IL-31, and tumor necrosis factor (TNF)-α in the ears was assayed.
RESULTS:
LOWE reduced AD symptoms based on ear thickness, histopathological analysis, and serum IgE levels. LOWE inhibited mast cell infiltration into the ear and elevation of serum histamine in AD model. Moreover, LOWE suppressed DFE/DNCB-induced expression of IL-4, IL-13, IL-31, and TNF-α in the ears.
CONCLUSIONS:
Our results showed that topical application of LOWE exerts beneficial effects in AD symptoms, suggesting that LOWE might be a candidate for the treatment of AD.
AuthorsEun-Ju Choi, Soyoung Lee, Hui-Hun Kim, Thoudam S K Singh, Jin Kyeong Choi, Hyun Gyu Choi, Won Mo Suh, Seung-Ho Lee, Sang-Hyun Kim
JournalJournal of ethnopharmacology (J Ethnopharmacol) Vol. 137 Issue 1 Pg. 802-7 (Sep 01 2011) ISSN: 1872-7573 [Electronic] Ireland
PMID21762765 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Anti-Allergic Agents
  • Antigens, Dermatophagoides
  • Dinitrochlorobenzene
  • Interleukin-13
  • Interleukins
  • Plant Extracts
  • Solvents
  • Tumor Necrosis Factor-alpha
  • interleukin-31, mouse
  • Water
  • Interleukin-4
  • Immunoglobulin E
  • Histamine
Topics
  • Administration, Cutaneous
  • Animals
  • Anti-Allergic Agents (administration & dosage, chemistry, isolation & purification, pharmacology)
  • Antigens, Dermatophagoides
  • Dermatitis, Atopic (chemically induced, genetics, immunology, pathology, prevention & control)
  • Dinitrochlorobenzene
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Ear
  • Female
  • Gene Expression Regulation (drug effects)
  • Histamine (blood)
  • Immunoglobulin E (blood)
  • Interleukin-13 (genetics)
  • Interleukin-4 (genetics)
  • Interleukins (genetics)
  • Lindera (chemistry)
  • Mast Cells (drug effects, immunology)
  • Mice
  • Mice, Inbred BALB C
  • Plant Extracts (administration & dosage, chemistry, isolation & purification, pharmacology)
  • Plants, Medicinal
  • Skin (drug effects, immunology, pathology)
  • Solvents (chemistry)
  • Time Factors
  • Tumor Necrosis Factor-alpha (genetics)
  • Water (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: