Abstract | BACKGROUND & AIMS: METHODS: RESULTS: At the time of transplant, the median log HBV DNA level was 3.5 copies/mL (range, 1.54-8.81); 21 patients (26%) had undetectable levels of HBV DNA. The cumulative rate of hepatitis B surface antigen ( HBsAg) loss was 86% and 91% after 1 and 2 years, respectively. Ten patients had reappearance of HBsAg. Eighteen patients (22.5%) were HBsAg positive at the time of their last examination; 17 of these had undetectable levels of HBV DNA, and the remaining patient had a low level of HBV DNA (217 copies/mL). There was no evidence of mutations at sites that confer resistance to entecavir among patients who were HBsAg positive. CONCLUSIONS:
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Authors | James Fung, Cindy Cheung, See-Ching Chan, Man-Fung Yuen, Kenneth S H Chok, William Sharr, Wing-Chiu Dai, Albert C Y Chan, Tan-To Cheung, Simon Tsang, Banny Lam, Ching-Lung Lai, Chung-Mau Lo |
Journal | Gastroenterology
(Gastroenterology)
Vol. 141
Issue 4
Pg. 1212-9
(Oct 2011)
ISSN: 1528-0012 [Electronic] United States |
PMID | 21762659
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Antiviral Agents
- Biomarkers
- DNA, Viral
- Hepatitis B Surface Antigens
- Immunosuppressive Agents
- entecavir
- Guanine
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Topics |
- Adult
- Aged
- Antiviral Agents
(adverse effects, therapeutic use)
- Biomarkers
(blood)
- Carcinoma, Hepatocellular
(surgery, virology)
- Chi-Square Distribution
- DNA, Viral
(blood)
- Female
- Guanine
(adverse effects, analogs & derivatives, therapeutic use)
- Hepatitis B Surface Antigens
(blood)
- Hepatitis B virus
(genetics, immunology)
- Hepatitis B, Chronic
(complications, diagnosis, drug therapy, surgery)
- Hong Kong
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Kaplan-Meier Estimate
- Liver Cirrhosis
(surgery, virology)
- Liver Neoplasms
(surgery, virology)
- Liver Transplantation
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Postoperative Care
- Time Factors
- Tomography, X-Ray Computed
- Treatment Outcome
- Viral Load
- Young Adult
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