Lymphocyte beta-2-adrenoceptors and plasma catecholamines in fetal hypoxia.

Abstract

Conclusive evidence has been furnished that the beta 2-adrenoceptor density in circulating lymphocytes is related to that of beta 2-adrenoceptors in tissues from the same subjects. This study was designed to evaluate the effect of fetal hypoxia on lymphocyte beta 2-adrenoceptor density. The material consisted of 8 hypoxic newborns, 4 delivered by vacuum extraction and 4 by Caesarean section, after approximately 10 h parturition. The control group consisted of 8 vaginally delivered newborns without hypoxia. Umbilical plasma adrenaline and noradrenaline were significantly elevated in the hypoxic newborns. Their lymphocyte beta 2-adrenoceptor density was lower (p less than 0.01) than that in the controls. A plausible explanation for this finding might be downregulation of beta 2-adrenoceptors because of elevated plasma catecholamine level.

• Authors: M Santala, S Saarikoski, O Castrén, M Parviainen
• Journal: Gynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 30 Issue 3 Pg. 150-4 ( 1990) ISSN: 0378-7346 [Print] Switzerland
• PMID: 2176172 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Receptors, Adrenergic, beta
• Norepinephrine
• Epinephrine

Topics

• Down-Regulation
• Epinephrine (blood)
• Female
• Fetal Hypoxia (blood)
• Humans
• Infant, Newborn
• Lymphocytes (chemistry)
• Male
• Norepinephrine (blood)
• Receptors, Adrenergic, beta (analysis)