[Effectiveness of the use of proteolytic enzymes in extracapsular cataract extraction].

Abstract

Experimental and clinical study of lekozim and collalysine proteolytic enzymes efficacies in extracapsular cataract extraction was carried out. Local application of these agents in irrigation aspiration of the cortical mass from the capsule sac equator not only simplified the technique of the most intricate stage of surgery, but also proved to be a sufficiently effective means of secondary cataract prevention. A follow-up of up to 3 years has shown secondary cataract development in 5 percent of patients after extracapsular cataract extraction administered lekozim, in 10 percent of those administered collalysine, and in 17.5 percent of cases with mechanical vacuum extraction. Lekozim and collalysine may be used in all the cases when extracapsular cataract extraction is possible.

• Authors: M M Krasnov, M L Dvali, G S Polunin, M N Ivanov, A A Fedorov, I A Shramko
• Journal: Vestnik oftalmologii (Vestn Oftalmol) 1990 Sep-Oct Vol. 106 Issue 5 Pg. 8-12 ISSN: 0042-465X [Print] Russia (Federation)
• Vernacular Title: Effektivnost' primeneniia proteoliticheskikh fermentov pri ékstrakapsuliarnoĭ ékstraktsii katarakty.
• PMID: 2175962 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• lekozim
• Peptide Hydrolases
• Papain
• Chymopapain
• Microbial Collagenase

Topics

• Adult
• Aged
• Animals
• Cataract Extraction (methods)
• Chymopapain (therapeutic use)
• Drug Combinations
• Follow-Up Studies
• Humans
• Microbial Collagenase (therapeutic use)
• Middle Aged
• Papain (therapeutic use)
• Peptide Hydrolases (therapeutic use)
• Rabbits
• Time Factors