Abstract | OBJECTIVE: METHODS: RESULTS: The serum levels of IFNα (50.2 ± 21.0) ng/L and IFNβ (10.7 ± 5.4) ng/L in IIM patients were significantly higher than those in normal controls (18.6 ± 3.6) ng/L, (3.9 ± 0.8) ng/L (P < 0.01). And the serum levels of IFNα (55.7 ± 21.9) ng/L and IFNβ (11.3 ± 2.3) ng/L in DM patients were significantly higher than those in PM patients (26.1 ± 8.2) ng/L, (6.2 ± 3.5) ng/L (P < 0.05). The serum levels of IFNα and IFNβ correlated with the presence of skin rash (P < 0.05). And their serum concentrations correlated positively with erythrocyte sedimentation rate (r = 0.442, P = 0.000; r = 0.562, P = 0.000) and C-reactive protein (r = 0.348, P = 0.004; r = 0.432, P = 0.005)respectively. The serum levels of IFNα and IFNβ decreased significantly after treatment in 12 PM/DM ( polymyositis/dermatomyositis) patients (P < 0.01). The mRNA expression levels of IFNα, IFNβ, IFNαR1 and STAT1 in PM/DM patients were higher than those in normal controls (P < 0.05). CONCLUSION: The expression levels of IFNα and IFNβ in PM/DM patients are significantly higher than those in normal controls. And the increments had correlations with disease activity and severity. STAT1 has been implicated in signal transduction of IFNα and IFNβ in the muscles of PM/DM patients.
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Authors | Ning Zu, Guo-chun Wang |
Journal | Zhonghua yi xue za zhi
(Zhonghua Yi Xue Za Zhi)
Vol. 91
Issue 17
Pg. 1157-60
(May 10 2011)
ISSN: 0376-2491 [Print] China |
PMID | 21756766
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- IFNAR1 protein, human
- STAT1 Transcription Factor
- STAT1 protein, human
- Receptor, Interferon alpha-beta
- Interferons
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Case-Control Studies
- Female
- Humans
- Interferons
(blood)
- Male
- Middle Aged
- Muscle, Skeletal
(metabolism)
- Myositis
(diagnosis, metabolism)
- Receptor, Interferon alpha-beta
(metabolism)
- STAT1 Transcription Factor
(metabolism)
- Young Adult
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