Synaptosomal-associated protein 25 gene polymorphisms and antisocial personality disorder: association with temperament and psychopathy.

Abstract

OBJECTIVE:

The molecular genetic of personality disorders has been investigated in several studies; however, the association of antisocial behaviours with synaptosomal-associated protein 25 (SNAP25) gene polymorphisms has not. This association is of interest as SNAP25 gene polymorphism has been associated with attention-deficit hyperactivity disorder and personality.

METHODS:

We compared the distribution of DdeI and MnII polymorphisms in 91 young male offenders and in 38 sex-matched healthy control subjects. We also investigated the association of SNAP25 gene polymorphisms with severity of psychopathy and with temperament traits: novelty seeking, harm avoidance, and reward dependence.

RESULTS:

The MnII T/T and DdeI T/T genotypes were more frequently present in male subjects with antisocial personality disorder (APD) than in sex-matched healthy control subjects. The association was stronger when the frequency of both DdeI and MnII T/T were taken into account. In the APD group, the genotype was not significantly associated with the Psychopathy Checklist-Revised scores, measuring the severity of psychopathy. However, the APD subjects with the MnII T/T genotype had higher novelty seeking scores; whereas, subjects with the DdeI T/T genotype had lower reward dependence scores. Again, the association between genotype and novelty seeking was stronger when both DdeI and MnII genotypes were taken into account.

CONCLUSION:

DdeI and MnII T/T genotypes may be a risk factor for antisocial behaviours. The association of the SNAP25 DdeI T/T and MnII T/T genotypes with lower reward dependence and higher novelty seeking suggested that SNAP25 genotype might influence other personality disorders, as well.

• Authors: Cengiz Basoglu, Ozgur Oner, Alpay Ates, Ayhan Algul, Yasin Bez, Mesut Cetin, Hasan Herken, Mehmet Emin Erdal, Kerim M Munir
• Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie (Can J Psychiatry) Vol. 56 Issue 6 Pg. 341-7 (Jun 2011) ISSN: 1497-0015 [Electronic] United States
• PMID: 21756448 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Synaptosomal-Associated Protein 25

Topics

• Adult
• Antisocial Personality Disorder (genetics)
• Criminals (psychology)
• Exploratory Behavior (physiology)
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Neuropsychological Tests
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Risk Factors
• Synaptosomal-Associated Protein 25 (genetics)
• Temperament (physiology)
• Turkey
• Young Adult